Can a pill and cash help dual users of E-Cigs and pot quit vaping?

NCT ID NCT06688539

Recruiting now Disease control Sponsor: Medical University of South Carolina Source: ClinicalTrials.gov ↗

First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study tests whether a common stop-smoking medication (varenicline) plus financial incentives can help adults aged 18-40 who use both e-cigarettes and cannabis quit vaping. All 105 participants will receive the drug and rewards for 12 weeks. Researchers will also track how cannabis use changes during the quit attempt.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: varenicline (a stop-smoking medication) and financial incentives
What this could lead to: If successful, this could provide an effective treatment for quitting e-cigarettes in people who also use cannabis, a group often excluded from cessation studies.
What could go wrong: This is a small Phase 4 trial with only 105 participants and no placebo group, so results may not apply broadly. Varenicline can cause side effects like nausea and sleep disturbances.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

cannabis dependence nicotine dependence Vaping

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

NICOTINE DEPENDENCE TOBACCO USE DISORDER

Contacts and locations

Locations

Behavioral Health Services of Pickens County
RECRUITING

Pickens, South Carolina, 29671, United States
MUSC Charleston
RECRUITING

Charleston, South Carolina, 29425, United States
MUSC Lancaster
RECRUITING

Lancaster, South Carolina, 29720, United States

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