TOBACCO USE DISORDER

This study tests whether practicing mindfulness meditation in a virtual reality environment can reduce cigarette cravings and help people quit smoking. Two hundred adults who smoke 10-40 cigarettes daily will either do six weekly VR mindfulness sessions or use standard nicotine p…

This study tests a program that helps African American smokers quit smoking and get screened for lung cancer. About 250 people will take part. The goal is to reduce lung cancer deaths in this group.

This study tests a smartphone-based reward program to help 36 veteran smokers quit before major elective surgery. Participants earn rewards for verified smoke-free days. The goal is to see if this approach is practical and helps reduce surgical risks.

This study tests whether varenicline (Chantix) helps people quit cigarettes and reduce cannabis use. About 200 adults in South Carolina who smoke and use cannabis will receive either the drug or a placebo, plus counseling and online tools. The goal is to see if the medication imp…

This study tests if a non-invasive brain stimulation technique called rTMS can help people with mental illness quit smoking. Forty daily smokers with a psychiatric condition will either receive rTMS or standard care. Researchers will also talk to patients and doctors to see if ad…

This study tests a free, internet-based program that uses mindfulness and behavioral strategies to help adults in Switzerland and Türkiye reduce or quit smoking and vaping. About 406 participants will be randomly assigned to the program or a control group. The program includes ei…

This study tests a program called Contingency Management that gives rewards to Veterans who quit smoking, verified by breath tests. It involves 108 participants and includes counseling and medication. The goal is to see if this approach helps Veterans stop smoking during lung can…

This study tests a new way to help veterans with PTSD stop smoking. It combines counseling, nicotine gum, and a noninvasive brain stimulation called TMS. Researchers want to see if this approach is practical and helps veterans stay smoke-free. About 50 veterans will take part.

This study tests whether adding ear acupressure (small seeds taped to ear points) to standard nicotine patches can reduce cravings, withdrawal symptoms, and anxiety in psychiatric inpatients who must stop smoking while in the hospital. About 60 adults aged 18-65 will be randomly …

This study tests whether cannabidiol (CBD) can help people who want to quit smoking reduce their cigarette use. Researchers will give 120 adults either CBD or a placebo twice daily for 56 days, and measure nicotine levels, cravings, and withdrawal symptoms. The goal is to find a …

This study tests a 5-day course of brain stimulation (deep TMS) to help adults aged 18-65 quit smoking. About 40 participants will receive 4 sessions per day for 5 days. The main goal is to see if the treatment is tolerable and acceptable, and to explore its effects on smoking ha…

This study tests whether clavulanic acid, a drug used in some antibiotics, can help adult smokers reduce their cigarette use. About 30 heavy smokers will receive either the drug or a placebo, and researchers will track changes in smoking behavior and brain activity using MRI scan…

This study is testing whether a compound from cannabis called cannabidiol (CBD) can help people stop smoking tobacco. Fifty adults who smoke more than 10 cigarettes a day and want to quit will take oral CBD during practice quit attempts. The goal is to see if CBD increases short-…

This study looks at whether cytisinicline, a drug used to help people quit smoking, can change how the brain responds to seeing smoking-related images. 64 daily smokers who are not trying to quit will take either the drug or a placebo and have their brain activity measured with a…

This study looks at how a beta-blocker (propranolol) and nicotine patches, alone or together, affect brain activity and cravings when smokers see smoking-related cues. Eighty daily smokers aged 21-60 will take part, but they won't try to quit or take the medications long-term. Th…

This study observes 200 people already taking psychedelics in other trials to understand how these drugs change brain processing. Researchers use brain scans, computer tasks, and interviews to measure shifts in learning, perception, and electrical activity. The goal is to predict…