Magic mushroom compound tested for smokers in pain

NCT ID NCT07118332

Recruiting now Symptom relief Sponsor: Yale University Source: ClinicalTrials.gov ↗

First seen Jun 25, 2026 · Last updated Aug 04, 2026 · Updated 3 times

Summary

This early-phase study at Yale will test whether a single 25mg dose of psilocybin is safe and well-tolerated in 10 veterans who smoke daily and have chronic pain. Researchers will monitor side effects and explore whether the drug can improve pain and boost motivation to quit smoking. Psilocybin is not yet approved for any medical use in the U.S.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: Psilocybin (the active ingredient in magic mushrooms)
What this could lead to: If it works, this could point toward a new way to ease chronic pain and help people quit smoking at the same time.
What could go wrong: This is a very early, small trial with only 10 people, so results may not apply widely. Psilocybin can cause intense psychological effects and is not yet approved for medical use.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

chronic pain syndrome nicotine dependence Pain

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

SMOKERS WITH CHRONIC PAIN

Contacts and locations

Locations

Department of Veterans Affairs
NOT_YET_RECRUITING

West Haven, Connecticut, 06516, United States
Department of Veterans Affairs
RECRUITING

West Haven, Connecticut, 06516, United States

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