Can switching meds or using E-Cigs help smokers quit for good?

NCT ID NCT06118502

Recruiting now Disease control Sponsor: Medical University of South Carolina Source: ClinicalTrials.gov ↗

First seen Jun 25, 2026 · Last updated Aug 13, 2026 · Updated 4 times

Summary

This study tests whether changing treatment can help smokers who relapse early after trying to quit. 544 participants who want to quit smoking will receive free nicotine patches, lozenges, varenicline, or e-cigarettes for 12 weeks. All visits are remote, and the study lasts 6 months with 8 surveys.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: nicotine replacement therapy (patches/lozenges), varenicline, or e-cigarettes
What this could lead to: If successful, this could provide a personalized strategy to help smokers who struggle to quit with standard medications.
What could go wrong: This is an early-stage behavioral study without a control group, so results may not prove which approach works best. E-cigarettes carry their own health risks.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

Cigarette Smoking nicotine dependence Smoking

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

CIGARETTE SMOKING SMOKING BEHAVIORS TREATMENT

Contacts and locations

Locations

Medical University of South Carolina
RECRUITING

Charleston, South Carolina, 29425, United States

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