Nicotine pouches under the microscope: do they hook new users?

NCT ID NCT07128329

Recruiting now Knowledge-focused Sponsor: Johns Hopkins University Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study at Johns Hopkins University is testing nicotine pouches (like Zyn) in 120 adults—60 regular smokers and 60 people who rarely use nicotine. Participants will use the pouches in two lab sessions while researchers measure how much nicotine gets into the blood, how appealing the product feels, and any withdrawal symptoms. The goal is to help the FDA understand the potential impact of these products on both users and non-users.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: Nicotine pouches (Zyn)
What this could lead to: If successful, this study could help regulators understand the potential risks and appeal of nicotine pouches, informing public health decisions.
What could go wrong: This is an early Phase 1 lab study with only 120 participants, so results may not reflect real-world use or long-term effects.

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Conditions

The condition(s) this trial relates to.

nicotine dependence

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

NICOTINE PHARMACODYNAMIC STUDY NICOTINE PHARMACOKINETIC STUDY NICOTINE POUCH SELF-ADMINISTRATION

Contacts and locations

Locations

Johns Hopkins University School of Medicine, Behavioral Pharmacology Research Unit (Bayview)
RECRUITING

Baltimore, Maryland, 21224, United States

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