NICOTINE DEPENDENCE

This study looked at whether switching from regular cigarettes to either low or high wattage e-cigarettes changes smoking habits and reduces exposure to harmful chemicals. 372 adult smokers who were not planning to quit took part. Researchers measured how many people stopped smok…

This small pilot study tested whether giving free e-cigarettes to people who still smoked after lung cancer screening would help them cut back. Fifteen participants who didn't plan to quit smoking were given NJOY ACE e-cigarettes for 4 weeks and followed for 8 weeks total. The st…

This study tested whether topiramate, a seizure medication, can help people who are dependent on both alcohol and nicotine. 236 adults took either a high or low dose of topiramate or a placebo for 18 weeks. The goal was to see if the drug helped them quit smoking and reduce heavy…

This study tested a special counseling program to help people living with HIV quit smoking. The program focused on reducing anxiety and depression, which often make it harder to stop smoking. 131 smokers with HIV took part to see if this approach helped them quit and stay smoke-f…

This study tested whether using lemongrass inhalers or liquid vapor could help adult smokers reduce their nicotine dependence and related health markers. Two hundred smokers aged 18-30 took part, using lemongrass products or no intervention. Researchers measured changes in nicoti…

This study looked at how nicotine addiction changes brain activity and which genes might make quitting harder. Researchers used brain scans and genetic tests on 159 people, including smokers trying to quit, smokers not trying to quit, former smokers, and non-smokers. The goal was…

This study looked at how nicotine from a standardized research e-cigarette (SREC) compares to nicotine from a person's usual e-cigarette brand. 32 regular e-cigarette users took part. Researchers measured nicotine levels in the blood, puffing patterns, and how people felt after v…

This study looked at how nicotine salt-based vaping products compare to free-base nicotine e-liquids. Fifteen daily vapers had their blood nicotine levels measured and reported how harsh or satisfying each product felt. The goal was to understand the abuse potential of different …

This study tested two types of brain stimulation (TMS) in 90 people who smoke, half with schizophrenia and half without. The goal was to see if TMS could change brain connections linked to nicotine use and reduce cravings. Participants had their cravings and thinking skills measu…

This study tested new computer tasks to see how drugs affect brain activity using MRI scans. Healthy volunteers aged 18 to 65, both drug users and non-users, performed memory and reaction-time tests while in a scanner. The goal was to develop reliable tools for future research on…