Menthol E-Cigarettes: do they change how you smoke?
NCT ID NCT04521647
First seen Jun 16, 2026 · Last updated Jun 22, 2026 · Updated 2 times
Summary
This study from Yale University looked at how menthol flavor in e-cigarettes affects smoking behavior and nicotine levels in people who smoke menthol cigarettes. Fourteen adult smokers participated in lab sessions where they used e-cigarettes with menthol or non-menthol flavor. Researchers measured nicotine in the blood to see if menthol changes how much nicotine gets absorbed. The goal was to better understand the link between nicotine metabolism and menthol, which could inform future smoking reduction strategies.
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Contacts and locations
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Locations
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Connecticut Mental Health Center
New Haven, Connecticut, 06519, United States
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
Nicotine (5%) in e-cigarettes with menthol flavor
What this could lead to
If successful, this could help explain how menthol flavoring influences smoking habits and nicotine intake, potentially guiding future smoking cessation strategies.
What could go wrong
This is a very small, early-phase study with only 14 participants, so results may not apply to the general population. It does not test long-term health effects or quitting success.
Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.