Menthol E-Cigarettes: do they change how you smoke?
NCT ID NCT04521647
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This study from Yale University looked at how menthol flavor in e-cigarettes affects smoking behavior and nicotine levels in people who smoke menthol cigarettes. Fourteen adult smokers participated in lab sessions where they used e-cigarettes with menthol or non-menthol flavor. Researchers measured nicotine in the blood to see if menthol changes how much nicotine gets absorbed. The goal was to better understand the link between nicotine metabolism and menthol, which could inform future smoking reduction strategies.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- Nicotine (5%) in e-cigarettes with menthol flavor
- What this could lead to
- If successful, this could help explain how menthol flavoring influences smoking habits and nicotine intake, potentially guiding future smoking cessation strategies.
- What could go wrong
- This is a very small, early-phase study with only 14 participants, so results may not apply to the general population. It does not test long-term health effects or quitting success.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
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Connecticut Mental Health Center
New Haven, Connecticut, 06519, United States
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