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E-Cigarettes may dull the Brain's response to smoking triggers

NCT ID NCT01782599

Ongoing Disease control Sponsor: Mclean Hospital Source: ClinicalTrials.gov ↗

First seen Jul 14, 2026 · Last updated Jul 15, 2026 · Updated 1 time

Summary

This study investigates whether using an electronic cigarette, along with a nicotine patch, can lessen smokers' automatic reactions to smoking-related cues like seeing someone smoke or smelling cigarette smoke. The researchers will measure these reactions through questionnaires, brain scans, and behavioral tests. The trial enrolls daily smokers aged 18 to 45 who are willing to use nicotine replacement therapy and e-cigarettes for 2 to 3 weeks.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance
dual nicotine patch and electronic cigarette
What this could lead to
If successful, this could show that e-cigarettes help smokers manage cravings triggered by smoking cues, potentially aiding smoking cessation.
What could go wrong
This is a small, early-stage study focused on cue reactivity, not long-term quitting. Results may not translate to real-world smoking reduction or cessation.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

nicotine dependence

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

NICOTINE DEPENDENCE

Contacts and locations

Locations

  • Mclean Hospital Imaging Center

    Belmont, Massachusetts, 02478, United States

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