Brain scans and genes may reveal why some smokers Can't quit
NCT ID NCT01867411
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This study looked at how nicotine affects brain activity and genes in smokers and non-smokers. Researchers used brain scans and genetic tests to understand why some people find it harder to quit smoking. The goal was to find biological markers that could predict quitting success and guide future treatments. About 159 people took part, including smokers trying to quit, smokers not trying to quit, former smokers, and non-smokers.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
What this could lead to
If successful, this could lead to better tools for predicting who will struggle to quit smoking and help develop more targeted treatments.
What could go wrong
This is an observational study, not a treatment trial. It may not directly lead to new therapies, and results may not apply to all smokers.
Disclaimer
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the original study
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Locations
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National Institute on Drug Abuse
Baltimore, Maryland, 21224, United States