Brain scans and genes may reveal why some smokers Can't quit
NCT ID NCT01867411
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This study looked at how nicotine affects brain activity and genes in smokers and non-smokers. Researchers used brain scans and genetic tests to understand why some people find it harder to quit smoking. The goal was to find biological markers that could predict quitting success and guide future treatments. About 159 people took part, including smokers trying to quit, smokers not trying to quit, former smokers, and non-smokers.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- What this could lead to
- If successful, this could lead to better tools for predicting who will struggle to quit smoking and help develop more targeted treatments.
- What could go wrong
- This is an observational study, not a treatment trial. It may not directly lead to new therapies, and results may not apply to all smokers.
This is an AI summary of the original study and may miss details. Read our disclaimer.
Get updates
Get notified about this study
Sign up to get updates when this study changes or when new studies for NICOTINE DEPENDENCE are added.
By submitting, you agree to our Terms of use
Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
-
National Institute on Drug Abuse
Baltimore, Maryland, 21224, United States
More trials for these conditions
Other studies related to the condition(s) this trial covers.
- Could a Nicotine-Free cigarette break the habit?
- Can sleep patterns explain racial gaps in smoking cravings?
- Quit smoking from your couch: teleconsultation put to the test
- Do newer IQOS devices change how people puff? study investigates
- Could a sleep medication curb nicotine cravings?
- E-Cigarettes may dull the Brain's response to smoking triggers