Nicotine speed and dose: key to smoking addiction?
NCT ID NCT05176418
First seen Jun 24, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This completed early-phase study at Yale University tested how different doses and delivery rates of IV nicotine affect its abuse potential and its ability to reduce smoking urges. Twenty daily smokers received low and high doses of nicotine at various speeds. The goal was to better understand nicotine's effects, which could inform future treatments for nicotine dependence.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- Nicotine (given intravenously)
- What this could lead to
- If successful, this could help understand how nicotine delivery methods influence addiction, potentially guiding future smoking cessation strategies.
- What could go wrong
- This is a very small, early-phase study (20 participants) that uses IV nicotine, not actual smoking, so results may not directly apply to real-world tobacco use.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
-
VA Healthcare System
West Haven, Connecticut, 06516, United States
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