Can a seizure drug help you quit drinking and smoking?

NCT ID NCT01182766

Completed Disease control Sponsor: University of Virginia Source: ClinicalTrials.gov ↗

First seen Jun 26, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study tested whether topiramate, a seizure medication, can help people who are dependent on both alcohol and nicotine. 236 adults received either a low or high dose of topiramate or a placebo, plus behavioral therapy. The goal was to see if the drug could reduce heavy drinking and help people quit smoking.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: topiramate (Topamax)
What this could lead to: If successful, this could point toward a treatment that helps people quit both alcohol and cigarettes at the same time.
What could go wrong: This trial is completed but results may not apply to everyone. Topiramate can cause side effects like dizziness and cognitive issues.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

alcohol abuse alcohol dependence nicotine dependence

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

ALCOHOL DEPENDENCE NICOTINE DEPENDENCE

Contacts and locations

Locations

University of California, San Diego

La Jolla, California, 92093, United States
University of Texas MD Anderson Cancer Center

Houston, Texas, 77030, United States
University of Virginia Center for Addiction Research & Education

Charlottesville, Virginia, 22911, United States
University of Virginia Center for Addiction Research & Education

Richmond, Virginia, 23294, United States

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