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Can E-Cigs help smokers in lung screening kick the habit? small study tests the idea

NCT ID NCT06472869

Disease control Sponsor: Massachusetts General Hospital Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 26, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This pilot study looked at whether giving free e-cigarettes to smokers who hadn't quit after lung cancer screening could help them smoke fewer regular cigarettes. Fifteen people who smoked at least 5 cigarettes a day were given NJOY ACE e-cigarettes for 4 weeks and asked to switch. The study measured how many enrolled, stayed in the trial, and how their smoking changed. It's a very early, small test to see if this approach is worth studying further.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
NJOY ACE e-cigarette with 5% nicotine
What this could lead to
If successful, this could point toward a way to help smokers who haven't quit reduce their cigarette use, potentially lowering health risks.
What could go wrong
This is a very small pilot study (15 people) with no control group, so results may not apply broadly. E-cigarettes have their own health risks and are not FDA-approved for smoking cessation.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

15 people

The number who actually took part.

Started

Sep 2024

Finished

Dec 2025

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

50 years and older

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Participants who completed the Screen Assist study (NCT03611881) and self-reported smoking cigarettes at the end of the study were asked to complete a survey to ascertain their potential interest in participating in a research study to test the effects of switching from combustible cigarettes (CC) to electronic cigarettes (EC). Individuals who expressed interest in switching to EC on that survey were screened for eligibility for this pilot study * Smoked ≥5 cigarettes/day in past month * Smoking status at study entry confirmed by breath carbon monoxide (CO) ≥ 6ppm * Willing to try switching from CC to EC for 4 weeks * Owns a mobile telephone * English speaking * Willing to travel to the Massachusetts General Hospital campus for 3 in-person visits. Exclusion Criteria: * Plans to quit smoking and has set a quit date in the next 30 days * Used smoking cessation treatment in the past 30 days * Used EC on \>2 days in the past 30 days * Hospitalized for acute coronary syndrome, unstable angina, congestive heart failure, stroke, pneumonia or chronic pulmonary disease/asthma exacerbation in the past 1 month * Not willing to abstain from smoking marijuana in the 24h before each study visit

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Conditions

The condition(s) this trial relates to.

Cigarette Smoking nicotine dependence Vaping

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Electronic cigarette use Nicotine dependence Smoking ( cigarette)

Contacts and locations

Locations

  • Massachusetts General Hospital

    Boston, Massachusetts, 02114, United States

More trials for these conditions

Other studies related to the condition(s) this trial covers.