Can E-Cigs help methadone patients kick tobacco?
NCT ID NCT05206435
First seen Jun 26, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This study looked at whether e-cigarettes or nicotine lozenges help people on methadone switch from smoking tobacco. 183 smokers were randomly assigned to use either JUUL e-cigarettes or nicotine lozenges for 6 weeks. Researchers measured nicotine exposure, lung function, and smoking behavior to see which method worked better.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
Electronic cigarette (JUUL 5% nicotine pods) and nicotine lozenges
What this could lead to
If successful, this could show that e-cigarettes are a viable option for reducing tobacco use in people on methadone, potentially lowering smoking-related health risks.
What could go wrong
This was a small, short-term study (6 weeks) with only 183 participants, so results may not apply broadly. E-cigarettes have their own health risks and may not help everyone quit smoking.
Disclaimer
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the original study
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Locations
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Butler Hospital
Providence, Rhode Island, 02906, United States