Can E-Cigs help methadone patients kick tobacco?

NCT ID NCT05206435

Completed Disease control Sponsor: Butler Hospital Source: ClinicalTrials.gov ↗

First seen Jun 26, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study looked at whether e-cigarettes or nicotine lozenges help people on methadone switch from smoking tobacco. 183 smokers were randomly assigned to use either JUUL e-cigarettes or nicotine lozenges for 6 weeks. Researchers measured nicotine exposure, lung function, and smoking behavior to see which method worked better.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: Electronic cigarette (JUUL 5% nicotine pods) and nicotine lozenges
What this could lead to: If successful, this could show that e-cigarettes are a viable option for reducing tobacco use in people on methadone, potentially lowering smoking-related health risks.
What could go wrong: This was a small, short-term study (6 weeks) with only 183 participants, so results may not apply broadly. E-cigarettes have their own health risks and may not help everyone quit smoking.

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Conditions

The condition(s) this trial relates to.

nicotine dependence Vaping

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

ELECTRONIC CIGARETTE USE NICOTINE DEPENDENCE

Contacts and locations

Locations

Butler Hospital

Providence, Rhode Island, 02906, United States

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