New study tests if menstrual cycle timing boosts Quit-Smoking success

NCT ID NCT05515354

First seen Jun 27, 2026 ยท Last updated Jun 27, 2026

Summary

This study tests whether starting nicotine replacement therapy (patches, gum, or lozenges) at a specific time in the menstrual cycle helps women quit smoking. About 1,200 women who smoke daily and have regular periods will be assigned to start their quit attempt during the follicular phase, luteal phase, or at their usual time. The goal is to see if cycle-timed quitting leads to higher abstinence rates.

What this could mean

Our plain-language read of the trial. This is informational only โ€” not medical advice or a prediction.

Active substance
Nicotine replacement therapy (patch, gum, lozenge)
What this could lead to
If successful, this could show that timing quit attempts to the menstrual cycle improves smoking cessation rates in women.
What could go wrong
This is a large Phase 4 trial, but the effect may be small or not generalizable to all women. Success depends on adherence and individual cycle variability.

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Conditions

The condition(s) this trial relates to.

nicotine dependence Smoking Cessation substance-related disorder Tobacco Smoking

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Contacts and locations

Locations

  • Centre for Addiction and Mental Health, Nicotine Dependence Clinic

    RECRUITING

    Toronto, Ontario, M6J 1H4, Canada

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