Could a nicotine patch replace opioids for Post-Surgery pain in smokers?

NCT ID NCT07250230

Recruiting now Symptom relief Sponsor: Henan Provincial People's Hospital Source: ClinicalTrials.gov ↗

First seen Jun 24, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This pilot study is testing whether a high-dose nicotine patch can reduce pain and the need for opioid painkillers in male smokers who are having chest surgery. The patch is given before and after surgery. The study will track how much pain medication participants use. It includes 80 male smokers aged 18-75 who are undergoing lung surgery.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: nicotine patch
What this could lead to: If it works, this could point toward a non-opioid way to manage pain after surgery for smokers, potentially reducing opioid side effects.
What could go wrong: This is a small pilot study with only 80 men, so results may not apply to everyone. Nicotine patches can cause side effects like skin irritation, dizziness, or nausea.

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Conditions

The condition(s) this trial relates to.

agnosia nicotine dependence pain agnosia Thoracic Diseases

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

ANALGESIA NICOTINE DEPENDENCE THORACIC DISEASES

Contacts and locations

Locations

Department of Anaesthesiology and Perioperative Medicine, People's Hospital of Zhengzhou University, Henan Provincial People's Hospital, Zhengzhou, Henan
RECRUITING

Zhengzhou, Henan, 450003, China

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