Mclean Hospital

This early-phase trial tests whether a daily vitamin B3 supplement called nicotinamide riboside can improve brain energy and reduce stress in people with mild cognitive impairment or mild Alzheimer's disease. Fifty participants will take the supplement for 12 weeks while research…

This study tested a smartphone app designed specifically for women to help them stay engaged with their medication for opioid use disorder. 39 women who had recently started medication treatment were randomly assigned to use the app plus standard care, or standard care alone. Res…

This study tested a computer program called BrainWorks that uses fun games to train thinking skills like memory, attention, and problem-solving. 72 adults with bipolar disorder and psychosis played these games over several sessions. Researchers measured changes in cognitive abili…

This study tested whether watching short online videos about borderline personality disorder (BPD) could help people recently diagnosed with the condition. 83 adults with BPD watched either BPD-specific videos or general mental health videos over two weeks and completed daily sur…

This study looked at how stress and negative emotions influence decision-making and eating behavior in women with binge-eating disorder. Researchers used brain scans to understand activity in reward and self-control areas during everyday choices. The goal was to learn more about …

This study looked at how pain influences opioid cravings in 89 adults with opioid use disorder and chronic pain. Participants attended a brief education session and then had their pain response and cravings measured. The goal was to better understand the connection between pain a…

This study looks at how mood and brain activity are linked in adolescent girls to find genetic and brain-based clues that might predict depression. One hundred healthy girls aged 12-14 and their mothers took part over six months. The teens completed interviews, questionnaires, co…

This study tested a program called CRAFT-EP, which helps families support a relative with early psychosis and substance use (like alcohol or cannabis). The program was delivered entirely through video calls. Researchers measured family members' depression and anxiety to see if th…

This study looked at 70 women with severe menstrual pain to understand why some don't get relief from NSAIDs like naproxen. Researchers measured pain changes after taking the drug or a placebo and tested how the brain processes pain. The goal is to find out if central sensitizati…

This study looked at 164 teenage girls with painful periods to understand how their brains process pain. Participants had pain tests and brain scans at the start and again after a year. The goal was to find patterns that might predict who will develop long-term chronic pain. No t…

This study tested whether therapists looking at patients' electronic messages (like texts and emails) during sessions could improve care. About 110 adults with anxiety or depression took part. The goal was to see if this approach helps patients feel better and strengthens their b…

This study followed 559 children and teens ages 6 to 19 in the McLean Anxiety Mastery Program to see if their anxiety and depression improved with treatment. Researchers compared patients who received treatment to those on a waitlist and checked if gains lasted three months after…

This completed Phase 4 trial tested whether brain scans and behavioral tasks can predict which antidepressant—sertraline or bupropion—works better for people with major depression and anhedonia (loss of pleasure). 133 participants took one of the two drugs for 8 weeks while resea…