Mclean Hospital

This study tested whether a special smartphone app designed for women could help them stick with their medication treatment for opioid addiction. About 40 women who had recently started treatment were randomly assigned to either use the app along with their usual care or to recei…

This study looked at whether an intensive group therapy program for children and teens with anxiety disorders was effective. Researchers followed over 550 young people (ages 6-19) in the program, comparing their progress to those on a waitlist. They measured changes in anxiety an…

This study tested a family training program delivered by video call. It aimed to help family members support a relative who is experiencing early psychosis and using substances like alcohol or cannabis. The goal was to see if the program improved family wellbeing and helped the r…

This study aimed to help doctors choose the right antidepressant for people with depression before they start treatment. Researchers used brain scans, computer tasks, and questionnaires to find markers that predict whether a person would respond better to one of two common antide…

This study tested whether watching short educational videos about borderline personality disorder (BPD) could help people manage their symptoms. Researchers enrolled 83 adults recently diagnosed with BPD and had them watch videos and complete daily surveys about their emotions fo…

This study tested if sharing and discussing a patient's text messages, emails, and social media chats with their therapist could improve mental health treatment. 110 adults in therapy for anxiety or depression were randomly assigned to either have their electronic communications …

This study investigated why common over-the-counter painkillers (like naproxen or ibuprofen) don't relieve menstrual cramps for up to 18% of women. Researchers tested 70 women with severe cramps to see if changes in how their brains process pain (called central sensitization) exp…

This study aimed to understand how stress and negative emotions affect the brain and decision-making in people with binge-eating disorder. Researchers used brain scans (fMRI) to measure activity in reward and control centers while 77 women made everyday decisions, like choosing s…

This study aimed to understand the connection between how people with opioid addiction experience pain and their cravings for opioids. Researchers enrolled 89 adults with both opioid use disorder and chronic pain. Participants attended a single session where they received brief e…

This study aimed to understand why some teenage girls experience severe menstrual pain and how it might lead to other body pains. Researchers followed 164 girls aged 13-19 for two years, using brain scans and pain sensitivity tests to look for patterns. The goal was to find brain…

This study aimed to understand what might predict depression in teenage girls by looking at their brain activity and genes. It involved 100 healthy girls aged 12-14, some with mothers who had depression and some without. The girls completed interviews, computer tasks, and had the…