Can brain scans and DNA predict teen depression?
NCT ID NCT01743716
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This study looks at how mood and brain activity are linked in adolescent girls to find genetic and brain-based clues that might predict depression. One hundred healthy girls aged 12-14 and their mothers took part over six months. The teens completed interviews, questionnaires, computer tasks, and provided saliva for genetic testing, plus an fMRI brain scan. The goal is to better understand what puts some teens at risk for depression.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
What this could lead to
If successful, this research could help identify early warning signs for depression in teens, leading to better prevention strategies.
What could go wrong
This is an observational study with a small sample of 100 healthy girls, so findings may not apply to everyone. It does not test a treatment.
Disclaimer
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This is a summary of
the original study
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Locations
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McLean Hospital
Belmont, Massachusetts, 02478, United States