Why do period pills fail some women? new study investigates
NCT ID NCT05900336
First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This study looked at 70 women with severe menstrual pain to understand why some don't get relief from NSAIDs like naproxen. Researchers measured pain changes after taking the drug or a placebo and tested how the brain processes pain. The goal is to find out if central sensitization—changes in how the nervous system handles pain—explains why some women don't respond to standard treatment.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
Sodium naproxen
What this could lead to
If successful, this could help identify women at risk for chronic pain and guide early treatments to prevent it.
What could go wrong
This is a small, completed Phase 4 study focused on understanding pain mechanisms, not testing a new treatment. Results may not apply to all women.
Disclaimer
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This is a summary of
the original study
.
Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Locations
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McLean Hospital
Belmont, Massachusetts, 02478, United States