Brain scans seek clues to why childhood trauma leads to depression
NCT ID NCT04713722
First seen Jun 26, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This study uses brain imaging to explore how severe childhood stress may cause chemical changes in the brain that increase depression risk. Researchers will scan the brains of 160 women aged 20-32, some with a history of childhood adversity and some without. The goal is to understand why some people stay resilient while others develop depression.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- What this could lead to
- If successful, this study could reveal brain mechanisms linking childhood stress to depression, pointing toward new targets for prevention or treatment.
- What could go wrong
- This is an observational imaging study, not a treatment trial. It may not directly lead to new therapies, and results may not apply to everyone.
This is an AI summary of the original study and may miss details. Read our disclaimer.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
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McLean Hospital
RECRUITINGBelmont, Massachusetts, 02478, United States
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