Could an antioxidant supplement boost brain function in schizophrenia?

NCT ID NCT06191965

Recruiting now Disease control Sponsor: Mclean Hospital Source: ClinicalTrials.gov ↗

First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study tests whether MitoQ, an antioxidant supplement, can improve thinking and memory in people with early schizophrenia who have signs of mitochondrial dysfunction. Researchers will give 50 participants either MitoQ or a placebo daily for 12 weeks, alongside their usual medications. The goal is to see if MitoQ helps with cognitive skills like attention and problem-solving.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: MitoQ (an antioxidant supplement)
What this could lead to: If it works, this could point toward a new way to improve thinking and memory in people with early schizophrenia.
What could go wrong: This is an early-phase trial with only 50 high-risk participants. MitoQ is a supplement, not a proven treatment, and may not improve cognition or symptoms.

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Conditions

The condition(s) this trial relates to.

Cognitive Dysfunction schizophrenia

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

COGNITIVE IMPAIRMENT MITOCHONDRIAL ALTERATION SCHIZOPHRENIA AND RELATED DISORDERS

Contacts and locations

Locations

McLean Hospital
RECRUITING

Belmont, Massachusetts, 02478, United States
University of Lausanne
NOT_YET_RECRUITING

Lausanne, Switzerland
Yale School of Medicine
NOT_YET_RECRUITING

New Haven, Connecticut, 06519, United States

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