Can a simple supplement ease bipolar depression? new trial tests magnesium B6

NCT ID NCT05837104

Recruiting now Symptom relief Sponsor: Mclean Hospital Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study tests whether adding magnesium vitamin B6 to usual treatment can reduce depression, anxiety, and stress in people experiencing their first episode of bipolar I disorder. Forty adults aged 18-50 will take either the supplement or a placebo three times daily for four weeks. The goal is to see if this safe, over-the-counter combination can improve mood symptoms early in the illness.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: magnesium vitamin B6
What this could lead to: If it works, this could point toward a simple, safe supplement to help manage mood symptoms early in bipolar I disorder.
What could go wrong: This is a small, early-phase trial with only 40 people over 4 weeks. The supplement may not outperform placebo, and results may not apply to everyone with bipolar disorder.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

anxiety disorder bipolar I disorder Depression

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

BIPOLAR I DISORDER DEPRESSION, ANXIETY STRESS

Contacts and locations

Locations

McLean Hospital
RECRUITING

Belmont, Massachusetts, 02478, United States

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