Can a simple supplement ease bipolar depression? new trial tests magnesium B6
NCT ID NCT05837104
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This study tests whether adding magnesium vitamin B6 to usual treatment can reduce depression, anxiety, and stress in people experiencing their first episode of bipolar I disorder. Forty adults aged 18-50 will take either the supplement or a placebo three times daily for four weeks. The goal is to see if this safe, over-the-counter combination can improve mood symptoms early in the illness.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
magnesium vitamin B6
What this could lead to
If it works, this could point toward a simple, safe supplement to help manage mood symptoms early in bipolar I disorder.
What could go wrong
This is a small, early-phase trial with only 40 people over 4 weeks. The supplement may not outperform placebo, and results may not apply to everyone with bipolar disorder.
Disclaimer
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Study contacts
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Contact
Phone: •••-•••-•••• Email: •••••@•••••
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Contact
Phone: •••-•••-•••• Email: •••••@•••••
Locations
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McLean Hospital
RECRUITINGBelmont, Massachusetts, 02478, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••
Contact Phone: •••-•••-•••• Email: •••••@•••••
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