BIPOLAR I DISORDER

This study follows 80 youth aged 9-19 with bipolar disorder to understand what affects their symptoms over a year. Participants receive medication management and talk therapy, and complete interviews and questionnaires. The goal is to improve diagnosis and treatment for young peo…

This study tests whether matching weight-loss medications to a person's specific obesity type (like 'hungry brain' or 'emotional hunger') helps people with bipolar disorder lose weight safely. About 100 adults aged 18-65 will take one of three FDA-approved drugs or join a weight-…

This study compares a new form of lithium (AL001) to the standard lithium carbonate in 20 adults with bipolar I disorder. Participants will take each drug for 14 days and undergo MRIs and blood tests to see how the drugs behave in the brain and body. The goal is to find out if AL…

This study compares a new drug combination (OLZ/SAM) to the standard drug olanzapine in teenagers with schizophrenia or bipolar I disorder. The main goal is to see if OLZ/SAM causes less weight gain over 12 weeks. About 220 teens aged 10-17 will take either OLZ/SAM or olanzapine …

This study tests a long-acting injection of cariprazine given once a month under the skin. It is for people with schizophrenia, bipolar I disorder, or major depressive disorder who are stable on other medications. The goal is to check safety, how the drug moves in the body, and i…

This study tests an experimental drug, NBI-1117568, to see if it can reduce manic symptoms in adults with bipolar I disorder who are hospitalized for a manic episode. About 150 participants will receive either the drug or a placebo for 21 days. The main goal is to measure changes…

This study tests whether a ketogenic diet (high fat, low carb) can improve brain energy and reduce psychiatric symptoms in people recently diagnosed with bipolar I or schizoaffective disorder. Fifty adults aged 18-45 will follow the diet for 12 weeks alongside their usual care. T…

This study tests an experimental drug called azetukalner to see if it can safely reduce depression in people with bipolar I or II disorder. About 400 adults currently in a depressive episode will receive either the drug or a placebo for 6 weeks. The main goal is to measure change…

This study tests an experimental drug called icalcaprant for treating depression in people with bipolar I or II disorder. About 195 adults will take either the drug or a placebo daily for 6 weeks. Researchers will measure mood changes using a standard depression scale and track a…

This study tests whether taking magnesium and vitamin B6 alongside standard treatment can reduce symptoms of depression, anxiety, and stress in people who have recently been diagnosed with bipolar I disorder. About 40 adults aged 18 to 50 with a first episode in the last 10 years…

This study tests an experimental drug called LB-102 to see if it can safely reduce depression symptoms in adults with Bipolar I Disorder who are currently having a major depressive episode. About 320 participants will be randomly assigned to receive either LB-102 or a placebo for…

This study tests whether time restricted eating (eating only during a 10-hour window each day) is a practical and helpful addition to usual treatment for people with bipolar disorder. Researchers will compare TRE to standard nutritional counseling in 40 adults with bipolar I or I…

This study tests whether cariprazine, a drug already approved for adults, can safely ease depressive episodes in children aged 10 to 17 with bipolar I disorder. About 380 participants will receive either the drug or a placebo for 6 weeks, with dose adjustments based on response. …

This study tests whether using a life history calendar—a simple grid that helps people recall important life events—can improve how accurately adults in Hong Kong remember and report past mental health problems. Researchers will compare the standard interview method with the cale…