New hope for bipolar mania: KarXT trial launches
NCT ID NCT07140913
First seen Oct 31, 2025 · Last updated May 13, 2026 · Updated 21 times
Summary
This study tests whether adding the drug KarXT to standard mood stabilizers (lithium, valproate, or lamotrigine) can better control manic episodes in people with Bipolar I disorder. About 424 adults hospitalized for mania will receive either KarXT or a placebo for 5 weeks. The main goal is to see if KarXT reduces mania symptoms more than placebo.
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This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Study contacts
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"University Multiprofile Hospital for Active Treatment - Dr. Georgi Stranski" EAD
RECRUITINGPleven, 5800, Bulgaria
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Arch Clinical Trials
RECRUITINGSt Louis, Missouri, 63141, United States
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Catalina Research Institute, LLC
RECRUITINGMontclair, California, 91763, United States
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CenExel iResearch, LLC
RECRUITINGSavannah, Georgia, 31405, United States
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Clinica Inventiva
RECRUITINGTuszyn, 95-080, Poland
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Clinical Innovations, Inc. dba CITrials
RECRUITINGBellflower, California, 90706, United States
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Clinical Innovations, Inc. dba CITrials
RECRUITINGRiverside, California, 92506, United States
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Community Clinical Research
RECRUITINGAustin, Texas, 78754, United States
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Goryokai Medical Corporation - Goryokai Hospital
RECRUITINGSapporo, Hokkaido, 002-8029, Japan
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Health Synergy Clinical Research
RECRUITINGWest Palm Beach, Florida, 33407, United States
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Inland Psychiatric Medical Group.
RECRUITINGChino, California, 91710, United States
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Kochi Health Sciences Center
RECRUITINGKochi, 781-8555, Japan
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Kuramitsu Hospital
RECRUITINGFukuoka, 819-0037, Japan
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Local Institution - 0001
NOT_YET_RECRUITINGSiena, Tuscany, 53100, Italy
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Local Institution - 0002
NOT_YET_RECRUITINGGenova, 16132, Italy
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Local Institution - 0003
NOT_YET_RECRUITINGMilan, Lombardy, 20122, Italy
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Local Institution - 0004
NOT_YET_RECRUITINGAncona, 60126, Italy
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Local Institution - 0005
NOT_YET_RECRUITINGPisa, Tuscany, 56126, Italy
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Local Institution - 0008
NOT_YET_RECRUITINGCórdoba, X5003DCE, Argentina
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Local Institution - 0009
NOT_YET_RECRUITINGMendoza, 5502, Argentina
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Local Institution - 0010
NOT_YET_RECRUITINGCórdoba, 5000, Argentina
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Local Institution - 0011
NOT_YET_RECRUITINGABB, Buenos Aires F.D., C1199ABB, Argentina
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Local Institution - 0012
NOT_YET_RECRUITINGCórdoba, 5000, Argentina
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Local Institution - 0052
NOT_YET_RECRUITINGHod HaSharon, Central District, 4534708, Israel
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Local Institution - 0053
NOT_YET_RECRUITINGAshkelon, Southern District, 7830604, Israel
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Local Institution - 0054
NOT_YET_RECRUITINGAalborg, North Denmark, 9000, Denmark
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Local Institution - 0083
NOT_YET_RECRUITINGJerusalem, 9112001, Israel
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Local Institution - 0084
NOT_YET_RECRUITINGPleven, 5800, Bulgaria
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Local Institution - 0085
NOT_YET_RECRUITINGClermont-Ferrand, Puy-de-Dôme, 63000, France
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Local Institution - 0086
NOT_YET_RECRUITINGTargovishte, 7700, Bulgaria
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Local Institution - 0087
WITHDRAWNMarseille, 13274, France
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Local Institution - 0088
NOT_YET_RECRUITINGHillerød, Capital Region, 3400, Denmark
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Local Institution - 0089
WITHDRAWNParis, 75014, France
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Local Institution - 0091
NOT_YET_RECRUITINGGlostrup Municipality, 2600, Denmark
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Local Institution - 0093
NOT_YET_RECRUITINGBucharest, Bucharest, 041914, Romania
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Local Institution - 0095
NOT_YET_RECRUITINGSanpetru /Brasov, 507190, Romania
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Local Institution - 0097
NOT_YET_RECRUITINGIași, 700282, Romania
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Local Institution - 0099
NOT_YET_RECRUITINGBucharest, 0, Romania
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Local Institution - 0101
NOT_YET_RECRUITINGSibiu, 550082, Romania
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Local Institution - 0102
NOT_YET_RECRUITINGBucharest, 011241, Romania
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Local Institution - 0103
NOT_YET_RECRUITINGRybnik, Silesian Voivodeship, 44-200, Poland
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Local Institution - 0107
NOT_YET_RECRUITINGYokohama, Kanagawa, 234-0051, Japan
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Local Institution - 0114
NOT_YET_RECRUITINGSantiago del Estero, 4200, Argentina
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Local Institution - 0116
NOT_YET_RECRUITINGKolkata, 700014, India
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Local Institution - 0118
NOT_YET_RECRUITINGKolkata, West Bengal, 700025, India
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Local Institution - 0121
NOT_YET_RECRUITINGMangalore, Karnataka, 575003, India
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Local Institution - 0123
NOT_YET_RECRUITINGMadurai, Tamil Nadu, 625020, India
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Local Institution - 0124
NOT_YET_RECRUITINGNovi Iskar, 1282, Bulgaria
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Local Institution - 0126
NOT_YET_RECRUITINGNice, Alpes-Maritimes, 06000, France
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Local Institution - 0129
NOT_YET_RECRUITINGMontpellier, 34295, France
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Local Institution - 0139
NOT_YET_RECRUITINGBunkyo-ku, Tokyo, 1138603, Japan
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Local Institution - 0141
WITHDRAWNKitakyushu-shi, Fukuoka, 8078555, Japan
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Local Institution - 0160
NOT_YET_RECRUITINGHouston, Texas, 77058, United States
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Local Institution - 0162
NOT_YET_RECRUITINGKyiv, Kyivska Oblast, 04080, Ukraine
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Local Institution - 0163
NOT_YET_RECRUITINGNove, Kirovohrad Oblast, 25491, Ukraine
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Local Institution - 0164
NOT_YET_RECRUITINGLviv, Lviv Oblast, 79021, Ukraine
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Local Institution - 0165
NOT_YET_RECRUITINGDnipro, Dnipropetrovsk Oblast, 49005, Ukraine
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Local Institution - 0167
NOT_YET_RECRUITINGSmila, Cherkasy Oblast, 20708, Ukraine
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Local Institution - 0168
NOT_YET_RECRUITINGVinnytsia, Vinnytsia Oblast, 21037, Ukraine
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Local Institution - 0169
NOT_YET_RECRUITINGHlevakha, Kyivska Oblast, 08631, Ukraine
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Local Institution - 0170
NOT_YET_RECRUITINGOdesa, 65006, Ukraine
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Local Institution - 0171
NOT_YET_RECRUITINGOdesa, 65006, Ukraine
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Local Institution - 0172
WITHDRAWNIizuka, Fukuoka, 820-8505, Japan
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Local Institution - 0176
NOT_YET_RECRUITINGtabashi City, Tokyo, 175-0091, Japan
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Local Institution - 0177
NOT_YET_RECRUITINGPoltava, 36000, Ukraine
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Local Institution - 0178
NOT_YET_RECRUITINGSkarzhyntsi, Khmelnytskyi Oblast, 32120, Ukraine
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Local Institution - 0180
NOT_YET_RECRUITINGBunkyo-ku, Tokyo, 113-8431, Japan
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Local Institution - 0181
NOT_YET_RECRUITINGSliven, 8800, Bulgaria
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Local Institution - 0184
NOT_YET_RECRUITINGKazanlak, Stara Zagora, 6100, Bulgaria
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Local Institution - 0185
NOT_YET_RECRUITINGBeijing, Beijing Municipality, 100088, China
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Local Institution - 0186
NOT_YET_RECRUITINGXi'an, Shaanxi, 710061, China
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Local Institution - 0187
NOT_YET_RECRUITINGShijiazhuang, Hebei, 050031, China
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Local Institution - 0188
NOT_YET_RECRUITINGTianjin, Tianjin Municipality, 300022, China
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Local Institution - 0190
NOT_YET_RECRUITINGBeijing, Beijing Municipality, 100096, China
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Local Institution - 0191
NOT_YET_RECRUITINGGuangzhou, Guangdong, 510370, China
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Local Institution - 0192
NOT_YET_RECRUITINGChengdu, Sichuan, 610036, China
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Local Institution - 0193
NOT_YET_RECRUITINGBaoding, Hebei, 71000, China
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Local Institution - 0195
NOT_YET_RECRUITINGChangsha, 450052, China
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Local Institution - 0196
NOT_YET_RECRUITINGNanjing, Jiangsu, 210029, China
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Local Institution - 0197
NOT_YET_RECRUITINGNingbo, Zhejiang, 315201, China
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Local Institution - 0199
NOT_YET_RECRUITINGBeersheba, Southern District, 8461144, Israel
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Local Institution - 0200
NOT_YET_RECRUITINGBnei Brak, 5154475, Israel
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Local Institution - 0201
NOT_YET_RECRUITINGKodaira, Tokyo, 187-8551, Japan
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Local Institution - 0203
NOT_YET_RECRUITINGBucharest, 41914, Romania
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Local Institution - 0205
NOT_YET_RECRUITINGIchikawa, Chiba, 272-8516, Japan
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Local Institution - 0206
NOT_YET_RECRUITINGTernopil, Ternopil Oblast, 460027, Ukraine
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NRC Research Institute
RECRUITINGOrange, California, 92868, United States
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Okehazama Hospital
RECRUITINGToyoake, Aichi-ken, 470-1168, Japan
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Omega Clinical Trials - La Habra
RECRUITINGLa Habra, California, 90631, United States
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Pillar Clinical Research - Bentonville
RECRUITINGBentonville, Arkansas, 72712, United States
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Pillar Clinical Research - Richardson
RECRUITINGRichardson, Texas, 75080, United States
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Pillar Clinical Research -Chicago
RECRUITINGChicago, Illinois, 60641, United States
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Pillar Clinical Research- Little Rock
RECRUITINGLittle Rock, Arkansas, 72204, United States
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Prime Clinical Research - Mansfield
RECRUITINGMansfield, Texas, 76063, United States
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Prof. Dr. Alexandru Obregia Psychiatry Hospital
RECRUITINGBucharest, Bucharest, 041914, Romania
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Prof. Dr. Alexandru Obregia Psychiatry Hospital
RECRUITINGBucharest, Bucharest, 041914, Romania
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Prof. Dr. Alexandru Obregia Psychiatry Hospital
RECRUITINGBucharest, Bucharest, 041914, Romania
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Proscience Research Group
RECRUITINGCulver City, California, 90230, United States
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Rainbow and Sea Hospital
RECRUITINGKaratsu, Saga-ken, 847-0031, Japan
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Richmond Behavioral Associates
RECRUITINGStaten Island, New York, 10314, United States
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Sheba Medical Center
RECRUITINGRamat Gan, Central District, 5265601, Israel
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South Florida Research Phase I-IV
RECRUITINGMiami, Florida, 33166, United States
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Velocity Clinical Research, Hallandale Beach
RECRUITINGHallandale, Florida, 33009, United States
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