Gold nanoparticles may make lithium therapy safer and more effective

NCT ID NCT07732933

Not yet recruiting Knowledge-focused Sponsor: Fondazione Policlinico Universitario Agostino Gemelli IRCCS Source: ClinicalTrials.gov ↗

First seen Jul 29, 2026 · Last updated Jul 30, 2026 · Updated 1 time

Summary

This lab study tests whether gold nanoparticles can carry lithium directly to brain cells, potentially reducing side effects. Researchers will use neural cells grown from blood samples of people with bipolar disorder and healthy volunteers, plus a mouse model of mania. The goal is to see if nanoparticle-delivered lithium works better than standard lithium salts at lower doses.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: lithium-loaded gold nanoparticles (LiG-AuNPs)
What this could lead to: If successful, this could pave the way for a safer, more targeted lithium therapy for bipolar disorder, reducing side effects.
What could go wrong: This is an early lab study using cells and mice, not humans. The nanoparticles may not work as hoped or could have unforeseen toxicity.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

bipolar disorder bipolar I disorder bipolar II disorder

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

BIPOLAR DISORDER (BD) BIPOLAR DISORDER (BPD)

Contacts and locations

Locations

Fondazione Policlinico Universitario Agostino Gemelli IRCCS

Roma, 00168, Italy

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