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Can a psychedelic compound ease suicidal thoughts in bipolar depression?
NCT ID NCT06706232
First seen Jul 30, 2026 · Last updated Aug 13, 2026 · Updated 3 times
Summary
This phase 2 trial is investigating whether two doses of psilocybin (25 mg each, given 4 weeks apart) combined with psychotherapy are safe and acceptable for people with bipolar II disorder who are experiencing depression and suicidal thoughts. The study enrolls 10 adults aged 25–70 and measures feasibility, retention, and changes in suicidal ideation and depression scores. It aims to see if this approach could offer a new way to help those with treatment-resistant symptoms.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- psilocybin (25 mg) given twice, 4 weeks apart, plus therapeutic support including preparatory and integration sessions
- What this could lead to
- If safe and acceptable, this approach could point toward a new treatment option for bipolar II depression with suicidal thoughts.
- What could go wrong
- This is a very small early-phase trial with only 10 participants, so results may not apply broadly. Psilocybin can cause intense psychological effects and is not yet proven safe in this population.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
-
The University of Texas Health Science Center at Houston
RECRUITINGHouston, Texas, 77006, United States
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