BIPOLAR DISORDER (BD)

This study tests a non-invasive brain stimulation method (temporal interference stimulation) aimed at improving metabolism in people with stable bipolar disorder who also have obesity. Researchers will measure changes in key metabolic molecules like GLP-1. The study enrolls 70 ad…

This study tests whether a 16-week ketogenic diet (low carbs, high fat, medium protein) can help teens aged 12–21 with bipolar disorder. Eighty participants will receive the diet plus standard medication, with coaching from dietitians and monthly checkups. Researchers will track …

People with bipolar disorder face double the risk of heart disease and die 14 years earlier on average. This study tests whether a personalized nutrition program—based on Brazil's dietary guidelines—can improve heart health markers like cholesterol, blood sugar, and body fat. Eig…

This pilot study tests a structured program to help young adults (ages 18-35) recently diagnosed with bipolar disorder transition from hospital to community care. The program includes group education sessions and one-on-one peer support over several months. Researchers want to se…

This study is testing a new tool that combines a blood test with a questionnaire to help primary care doctors correctly identify bipolar disorder in people who are currently experiencing depression. The goal is to see if this tool can accurately tell the difference between bipola…

This study tests whether eating only during an 8-hour window each day (time-restricted eating) can help people with bipolar disorder who are overweight and depressed lose weight and improve their mood. Forty adults will be randomly assigned to either follow this eating pattern fo…

This study tests whether giving flumazenil, a drug that reverses the effects of benzodiazepines, right before electroconvulsive therapy (ECT) can reduce cognitive side effects like memory loss in hospitalized patients with depression. About 145 participants will either continue t…

This study tests whether a portable, home-use brain stimulation device (tDCS) can safely reduce depressive symptoms in people with bipolar disorder. 212 adults with bipolar depression will use either the active device or a sham (placebo) version at home for 10 weeks. The goal is …

This study tests whether a three-week virtual reality cognitive training program, combined with a daily supplement (sodium butyrate), can improve memory, attention, and thinking speed in 160 adults aged 50+ who have had depression or bipolar disorder but are currently stable. Par…

This study tests a new idea: that Borderline Personality Disorder (BPD) may be a form of addiction to close relationships, similar to substance use disorders. Researchers will give a special questionnaire to 194 people—those with BPD, those with bipolar disorder, and healthy volu…

This study is testing a new way to help families decide if their children should be screened for early signs of mental health problems. The children are ages 7 to 21 and have a parent with bipolar disorder. The researchers are creating a video and FAQ to help parents understand t…

This observational study is testing whether a computer can predict when someone with bipolar disorder might relapse. Researchers will collect voice, text, eye movements, and brain signals from 200 patients and 200 healthy volunteers. The goal is to build a model that spots early …

This study is adapting and validating a short questionnaire called the Hypomanic Personality Scale (HPS-6) for Romanian speakers. The goal is to see if this 6-question tool can reliably identify adults at higher risk for bipolar disorder. Researchers will enroll 50 people aged 18…

This study is measuring how well people with schizophrenia or bipolar disorder can exercise, breathe, and manage daily life. Researchers will test lung function, breathing muscle strength, and walking ability in 150 adults. The goal is to find physical limitations that could be i…

This study is looking at how people with conditions like schizophrenia, bipolar disorder, depression, and neurological diseases (such as Alzheimer's or stroke) perform on computer-based thinking tests. The goal is to create a detailed map of cognitive strengths and weaknesses acr…

This study is tracking 1,000 teenagers hospitalized for depression or bipolar disorder. Researchers will collect blood samples, brain scans, wearable device data, and psychological tests to identify patterns that predict how well a teen responds to treatment. The goal is to find …

This observational study will collect genetic and health information from 50,000 people with serious mental illnesses like bipolar disorder, schizophrenia, major depression, and dementia. Researchers will link this data to electronic health records to find patterns and risk facto…

This study uses a special pillbox that records when people with bipolar disorder take their lithium. Over four weeks, 50 participants will use the pillbox and get weekly phone calls to compare what they remember with what the box recorded. The goal is to see how well people stick…