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Can a reversal drug protect memory during ECT for depression?

NCT ID NCT07619092

Recruiting now Symptom relief Sponsor: Anders Jørgensen Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study tests whether giving flumazenil, a drug that reverses the effects of benzodiazepines, right before electroconvulsive therapy (ECT) can reduce cognitive side effects like memory loss in hospitalized patients with depression. About 145 participants will either continue their benzodiazepine and receive flumazenil before ECT, or stop the benzodiazepine beforehand as usual. The goal is to see if flumazenil helps protect thinking and memory without reducing ECT's effectiveness.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance
Flumazenil
What this could lead to
If it works, this could offer a way to reduce memory and thinking side effects of ECT for depression, making the treatment easier to tolerate.
What could go wrong
This is a small, early-stage trial. The benefit may be small or not appear, and flumazenil could cause anxiety or other side effects. Results may not apply to all patients.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

bipolar disorder major depressive disorder

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

AUTOBIOGRAPHICAL MEMORY BIPOLAR DISORDER (BD) COGNITION DEPRESSION - MAJOR DEPRESSIVE DISORDER ECT ELECTROCONVULSIVE THERAPY FUNCTIONAL MAGNETIC RESONANCE IMAGING (FMRI) INPATIENTS TREATMENT OUTCOME

Contacts and locations

Locations

  • Mental Health Centre Copenhagen, Bispebjerg and Frederiksberg Hospital

    RECRUITING

    Frederiksberg, Capital Region, 2000, Denmark

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