COGNITION

This study investigates whether combining intranasal insulin (delivered as a nose spray) with high-intensity exercise can improve brain blood flow, insulin sensitivity, and thinking skills in older adults with type 2 diabetes. Participants aged 55–80 will receive either insulin o…

This study looks at whether eating wild blueberries can improve heart health, thinking skills, and gut bacteria in Black and White adults aged 45-65 with high blood pressure. Participants will eat blueberries daily and have their blood pressure, artery stiffness, and cognitive fu…

This study tests whether eating peanuts and peanut products daily for six months can improve blood sugar, blood pressure, thinking skills, and gut health in people with prediabetes. Researchers will enroll 72 adults from diverse racial backgrounds. Participants will eat different…

This study tests whether a daily dose of freeze-dried wild blueberry powder can improve blood sugar, blood pressure, and brain function in women with prediabetes. Thirty overweight women aged 20-65 will take either the blueberry powder or a placebo for six weeks. Researchers will…

This global study tests whether applying a sunlight-reflecting coating to roofs can lower indoor temperatures and improve health. Researchers will enroll 3,200 households in five hot cities across Africa, Asia, Latin America, and the Pacific. They will measure heart rate, blood s…

This study is testing whether a dietary supplement called AP-Brain can improve memory and thinking in healthy adults aged 40 to 79 who feel their memory is slipping. Participants will take different doses (1g, 3g, or 5g) or a placebo for 56 days and complete computer-based memory…

This study tests whether a dietary supplement called AP-Brain can improve cognitive function in healthy adults aged 18-39 who feel they have attention problems. Participants will take different doses of AP-Brain or a placebo for 56 days and complete memory and attention tests. Th…

This study tests whether giving flumazenil, a drug that reverses the effects of benzodiazepines, right before electroconvulsive therapy (ECT) can reduce cognitive side effects like memory loss in hospitalized patients with depression. About 145 participants will either continue t…

This study looks at whether adding a special whey protein supplement to a high-fat meal can improve markers of heart and brain health in postmenopausal women who are overweight and at moderate risk for heart disease. Sixteen women will each try the supplement and a placebo on sep…

This study tests whether giving 3-5 year olds a daily prebiotic fiber powder for several weeks can improve their mood, sleep, emotional control, and thinking. Parents of 106 children with low fiber intake will report on their child's behavior and emotions. The study is double-bli…

This study looks at whether taking ETAS® daily for 12 weeks can improve memory, mood, and brain activity in healthy adults aged 60 to 80 who have mild memory complaints. Participants will be randomly assigned to receive either ETAS® or a placebo, and will undergo memory tests, br…

This study is testing whether adding breathing exercises to balance training can improve thinking skills in people aged 65 and older. Forty participants will do 30 minutes of balance exercises plus 15 minutes of breathing exercises twice a week for 8 weeks. Researchers will measu…

This study tests whether combining aerobic, strength, and balance exercises with cognitive training (dual-tasking) can improve gait, balance, and cognition in people with mild cognitive impairment due to Alzheimer's. Forty-five participants will be split into three groups: one do…

This study tests whether a special type of artificial light that changes throughout the day can improve sleep, body clock function, and overall well-being in frail older adults. Researchers will enroll 300 people over age 65 who are staying in hospital rooms equipped with this dy…

This study looks at whether eating nuts can help reduce symptoms of depression, anxiety, and stress, and improve memory and thinking skills in young adults. Researchers will enroll 135 university students aged 18 to 25 and measure changes in mood, cognitive function, and a brain-…

This study tests whether immersive virtual reality (VR) exercise can reduce pain, improve shoulder function, sleep, and thinking in people with mild to moderate frozen shoulder (grade 1-2). About 36 adults aged 18-64 who are new to physiotherapy will use VR headsets to gamify the…

This study tests an 18-week program where people with mild dementia and their family caregivers do sport stacking (a fast cup-stacking game) together at home. The goal is to see if it improves thinking skills, mood, and quality of life for both the person with dementia and their …

This study tests whether a daily dietary supplement can improve memory, thinking, and emotional well-being in healthy adults aged 55 and older. Sixteen participants will take the supplement for 45 days and complete memory and mood tests at the start and end. The goal is to see if…

This study compares two ways of delivering a combined attention and strategy training program to veterans with mild traumatic brain injury and PTSD. One group receives the training in person, the other via telehealth. The goal is to see if remote delivery works just as well for i…

This study tests whether 6 months of daily, home-based transcranial direct current stimulation (tDCS) can improve cognitive and motor function in 128 older adults (ages 65-90) with motoric cognitive risk syndrome, a condition that raises dementia risk. Participants use a headset …

This study from Stanford University is looking at how a 6-week math training program changes brain activity and thinking skills in children with math learning disabilities (dyscalculia). About 180 children aged 6-12 will do math problems on a tablet at home and get weekly one-on-…

This study is for adults with depression who have recently attempted suicide. It tests a group program that teaches emotion regulation and values to improve daily functioning and prevent future suicide attempts. Researchers will also measure thinking skills, quality of life, and …

This study looks at whether low magnesium in the blood is linked to memory, attention, and other thinking problems after a stroke. Researchers will measure magnesium levels and give cognitive tests to 80 stroke patients over several weeks. The goal is to understand if magnesium d…

This study looks at how the antipsychotic medication haloperidol may block insulin action in the brain, which could explain why these drugs often cause weight gain and diabetes. Researchers will give healthy volunteers either haloperidol or a placebo and use brain scans to measur…

This study follows 100 adults with treatment-resistant depression who are prescribed esketamine nasal spray in real-world clinics. Researchers will track how well the drug works, who responds best, and how it affects daily life and thinking. The goal is to improve personalized ca…

This study looks at how chronic marijuana use changes brain inflammation and thinking abilities in people with HIV. Researchers will use brain scans and blood tests to measure brain health in 220 adults. The goal is to understand the effects, not to test a new treatment.

This study is testing whether a smartphone app can help firefighters improve their sleep, reduce stress, and boost thinking skills. About 50 firefighters will use the app and report how well it works. The goal is to see if the program is easy to use and helpful for real-life fire…

This study looks at whether taking L-serine (an amino acid) with or without strength training can improve memory, thinking, and physical fitness in healthy adults aged 65 to 85. Over 48 weeks, participants will take either a placebo, L-serine, or L-serine plus strength training. …

This study is testing whether a single dose of modafinil, a drug that promotes wakefulness, can change how healthy people perform decision-making tasks and alter their brain activity. Researchers will use EEG caps to measure brain waves while participants play computer-based brai…

This study is testing whether a special nutrition shake given after surgery can help older adults (70+) regain physical and mental function faster. Half of the 100 participants will receive the shake daily for 30 days, while the other half will follow standard recovery advice. Th…

This study tests whether shining a special light on the head (transcranial photobiomodulation) can improve blood flow and thinking in older adults. 30 healthy volunteers aged 21-85 will receive either real or fake light therapy sessions every other day for 4 weeks. Researchers wi…

This study is creating a large, diverse group of 1,000 older adults in Tennessee to help researchers better understand Alzheimer's disease. Participants, who may be healthy, have mild memory problems, or have Alzheimer's, will be followed yearly with tests like brain scans and bl…

This study looks at how obstructive sleep apnea (OSA) affects thinking skills and empathy in children aged 3 to 12. Researchers will compare surgery versus medication for mild OSA and track changes over 12 months. They will also use EEG to find brain signals linked to sleep apnea…

This study looks at how healthy adults plan several moves ahead when playing a strategy game called Four-in-a-Row (like Connect Four). Researchers will record brain activity and eye movements to understand the thinking process. The goal is to learn more about how the brain simula…

This study follows 874 children aged 3 to 5 over one year to understand how using interactive devices like tablets and smartphones affects their thinking, social skills, and physical health. Parents will install an app to track device use, and researchers will measure development…

This study tests a 12-week mobile app program for parents of 3-4 year olds who currently meet few movement guidelines. Children wear activity trackers, and parents get weekly tips and goals through the app. The goal is to see if the app helps kids get more physical activity, bett…