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Exercise plus brain games may slow Alzheimer's decline

NCT ID NCT07334392

Symptom relief Sponsor: University of Patras Source: ClinicalTrials.gov ↗

What the study statuses mean

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Recruitment status, easiest to join first

Recruiting now This study
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study tests whether combining aerobic, strength, and balance exercises with cognitive training (dual-tasking) can improve gait, balance, and cognition in people with mild cognitive impairment due to Alzheimer's. Forty-five participants will be split into three groups: one doing the combined program, one doing exercise only, and a control group receiving only educational materials. The program lasts three months, with sessions twice a week.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
therapeutic exercise program (aerobic, strengthening, balance, and cognitive training)
What this could lead to
If it works, this could point toward a non-drug way to help people with early Alzheimer's maintain their physical and mental function longer.
What could go wrong
This is a small, early-stage trial with only 45 participants, so results may not apply to everyone. The improvements may be modest or not last long-term.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

About 45 people

The number the study aims to enrol. It can still change while the study runs.

Started

Dec 2025

Expected to finish

Nov 2026

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

50 years and older

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * individuals \> 50 years old * people with confirmed cognitive impairment, as evidenced by values within normal limits on the Montreal Cognitive Assessment test (MOCA ) \>20 * stable medication in the last month * independent walking Exclusion Criteria: * people with dementia * people suffering from chronic mental illness (e.g. schizophrenia, bipolar disorder) * people suffering from a neurological disorder or injuries (e.g. multiple sclerosis, Parkinson's, traumatic brain injury) * people with clinical depression (as determined by the Neuropsychiatric Inventory (NPI) assessment and medical diagnosis) * people who have had recent surgery * people with insufficient knowledge of the Greek language

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Conditions

The condition(s) this trial relates to.

cognitive disorder Cognitive Dysfunction Motor Activity

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Balance Cognition Mild cognitive impairment Walking

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The places running it

    1 site. The list below names each one and where it is.

  2. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  3. A doctor treating you

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Contacts and locations

Locations

  • Department of Physiotherapy, University of Patras

    RECRUITING

    Pátrai, Greece

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