Could a nose spray and walking protect the aging brain?
NCT ID NCT07675499
First seen Jun 30, 2026 · Last updated Jul 01, 2026 · Updated 1 time
Summary
This study investigates whether combining intranasal insulin (delivered as a nose spray) with high-intensity exercise can improve brain blood flow, insulin sensitivity, and thinking skills in older adults with type 2 diabetes. Participants aged 55–80 will receive either insulin or a placebo spray twice daily plus a 16-week exercise program. The goal is to see if this dual approach helps protect the brain from age-related decline.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
intranasal insulin
What this could lead to
If it works, this combination could point toward a non-drug way to protect brain health and thinking skills in people with type 2 diabetes.
What could go wrong
This is a mid-stage trial with only 60 participants, so results may not apply to everyone. The approach is experimental and may not show clear benefits.
Disclaimer
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This is a summary of
the original study
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Study contacts
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Contact
Phone: •••-•••-•••• Email: •••••@•••••
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Contact
Phone: •••-•••-•••• Email: •••••@•••••
Locations
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Center for Advanced Human Brain Imaging Research
RECRUITINGPiscataway, New Jersey, 08854, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Institute for Food, Nutrition, and Health
RECRUITINGNew Brunswick, New Jersey, 08901, United States
Contact Email: •••••@•••••
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Robert Wood Johnson University Hospital Clinical Research Center
RECRUITINGNew Brunswick, New Jersey, 08091, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Rutgers University Loree Gymnasium
RECRUITINGNew Brunswick, New Jersey, 08901, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••