Could a nose spray and walking protect the aging brain?

NCT ID NCT07675499

Recruiting now Disease control Sponsor: Rutgers, The State University of New Jersey Source: ClinicalTrials.gov ↗

First seen Jun 30, 2026 · Last updated Jul 01, 2026 · Updated 1 time

Summary

This study investigates whether combining intranasal insulin (delivered as a nose spray) with high-intensity exercise can improve brain blood flow, insulin sensitivity, and thinking skills in older adults with type 2 diabetes. Participants aged 55–80 will receive either insulin or a placebo spray twice daily plus a 16-week exercise program. The goal is to see if this dual approach helps protect the brain from age-related decline.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: intranasal insulin
What this could lead to: If it works, this combination could point toward a non-drug way to protect brain health and thinking skills in people with type 2 diabetes.
What could go wrong: This is a mid-stage trial with only 60 participants, so results may not apply to everyone. The approach is experimental and may not show clear benefits.

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Conditions

The condition(s) this trial relates to.

cognitive disorder Insulin Resistance type 2 diabetes mellitus

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

BRAIN BLOOD FLOW COGNITION INSULIN SENSITIVITY/RESISTANCE TYPE 2 DIABETES

Contacts and locations

Locations

Center for Advanced Human Brain Imaging Research
RECRUITING

Piscataway, New Jersey, 08854, United States
Institute for Food, Nutrition, and Health
RECRUITING

New Brunswick, New Jersey, 08901, United States
Robert Wood Johnson University Hospital Clinical Research Center
RECRUITING

New Brunswick, New Jersey, 08091, United States
Rutgers University Loree Gymnasium
RECRUITING

New Brunswick, New Jersey, 08901, United States

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