Insulin sensitivity/resistance
Clinical trials for Insulin sensitivity/resistance explained in plain language.
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Heart hormone boost may cut diabetes risk in black individuals — a trial puts it to the test
Disease control Recruiting nowBlack individuals often have lower levels of natriuretic peptides, heart hormones that help regulate metabolism. This trial tests whether raising those hormone levels with a drug called sacubitril/valsartan can improve insulin sensitivity and energy expenditure. About 200 Black a…
Matched conditions: INSULIN SENSITIVITY/RESISTANCE
Phase 2 • Sponsor: University of Alabama at Birmingham • Aim: Disease control
Last updated Jul 30, 2026 00:00 UTC
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Could a nose spray and walking protect the aging brain?
Disease control Recruiting nowThis study investigates whether combining intranasal insulin (delivered as a nose spray) with high-intensity exercise can improve brain blood flow, insulin sensitivity, and thinking skills in older adults with type 2 diabetes. Participants aged 55–80 will receive either insulin o…
Matched conditions: INSULIN SENSITIVITY/RESISTANCE
Phase 2/3 • Sponsor: Rutgers, The State University of New Jersey • Aim: Disease control
Last updated Jul 02, 2026 00:00 UTC
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Could a stomach tuck reverse fatty liver?
Disease control Recruiting nowThis study tests whether a minimally invasive procedure called endoscopic sleeve gastroplasty (ESG), which reduces stomach size by 70%, can help reverse fatty liver disease (MASH) in people with obesity. Researchers will compare ESG plus lifestyle changes to lifestyle changes alo…
Matched conditions: INSULIN SENSITIVITY/RESISTANCE
Sponsor: Pichamol Jirapinyo, MD, MPH • Aim: Disease control
Last updated Jun 27, 2026 14:02 UTC
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HIIT may boost muscle sugar storage and cut liver fat in type 2 diabetes
Disease control Recruiting nowThis study tests whether 12 weeks of high-intensity interval training (HIIT) can improve how muscles store sugar (glycogen) and use insulin in people with type 2 diabetes. Researchers will also check if HIIT reduces liver fat. The trial involves 36 overweight or obese adults aged…
Matched conditions: INSULIN SENSITIVITY/RESISTANCE
Sponsor: Finis Terrae University • Aim: Disease control
Last updated Jun 27, 2026 11:02 UTC
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What makes insulin stop working? scientists investigate healthy people
Knowledge-focused Recruiting nowThis study looks at why some healthy adults develop insulin resistance, a condition where the body doesn't use insulin well. Researchers will ask 80 participants to either reduce physical activity for 14 days or eat a high-fat diet for 3 days. They will then measure changes in in…
Matched conditions: INSULIN SENSITIVITY/RESISTANCE
Sponsor: University of Copenhagen • Aim: Knowledge-focused
Last updated Aug 19, 2026 00:00 UTC
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Fish oil may counteract hidden diabetes risk from low bad cholesterol
Knowledge-focused Recruiting nowThis study looks at why having low 'bad' cholesterol (LDL) might actually increase the risk of type 2 diabetes. Researchers think LDL entering fat tissue may cause problems that lead to diabetes. They will test if taking omega-3 fish oil supplements for 6 months can reduce that r…
Matched conditions: INSULIN SENSITIVITY/RESISTANCE
Sponsor: Institut de Recherches Cliniques de Montreal • Aim: Knowledge-focused
Last updated Jun 27, 2026 11:01 UTC