COGNITION

This study tests whether special reflective roof coatings, called cool roofs, can lower indoor temperatures and improve health for people living in hot areas of Mexico. About 800 households will take part, with some getting the cool roof and others not. Researchers will measure e…

This study tests if a brief, phone-delivered insomnia treatment (BBTI) can improve sleep and thinking in older adults with HIV compared to a mindfulness approach. 214 participants aged 50+ with insomnia will complete 4 weeks of therapy and be followed for a year. The goal is to s…

This study looks at whether taking certain nutritional supplements for 28 days can help adults who have mild sleep issues sleep better, think more clearly, and feel less stressed. About 68 adults aged 25 to 60 who describe themselves as poor sleepers will take either a supplement…

This study tests whether a supplement called AP-Brain can improve memory and thinking in healthy adults aged 40 to 79 who feel their memory is slipping. About 120 participants will take either a low, medium, or high dose of AP-Brain or a placebo daily for 56 days. Their memory an…

This study will test whether a 16-week Pilates program done at home via video calls can improve walking, balance, fatigue, and pain in people with multiple sclerosis (MS). About 50 adults with mild to moderate MS will be assigned to either the Pilates group or a waitlist. Researc…

This study tests a non-invasive brain stimulation technique called tDCS, given remotely at home, to improve thinking skills like memory and attention in veterans with mild traumatic brain injury (mTBI) and PTSD. About 46 veterans will receive either real or fake tDCS paired with …

This study tests a supplement called AP-Brain in healthy adults aged 18-39 who say they have trouble paying attention. Researchers want to see if taking it daily for 56 days improves memory and focus compared to a placebo. 120 participants will take one of three doses or a dummy …

This study aims to see if a digital memory test called DiaMem gives consistent results when taken multiple times. Researchers will have 30 adults aged 60 and older take memory tests daily for 6 days. The goal is to understand how reliable the tool is for future use in assessing m…

This study looks at how two medications, modafinil and d-serine, affect decision-making and brain activity in people who have had psychosis symptoms for less than five years. Participants will take a single dose of each medication or a placebo, then play computer brain games and …

This study looks at whether different types of exercise can help protect the body and mind from the negative effects of not getting enough sleep. Researchers will measure blood sugar control, thinking speed and accuracy, and blood vessel health in 48 healthy adults aged 20-45. Pa…

This study looks at how doing mental tasks—like naming objects or remembering words—changes the way people with Parkinson's disease walk. Researchers will compare 30 people with Parkinson's to healthy volunteers of the same age and sex. The goal is to find out which type of think…

This study looks at whether eating mangoes can improve immune function and thinking skills in healthy young adults aged 18 to 30. Researchers will measure changes in immune cells and cognitive test scores after mango consumption. The goal is to understand potential benefits of ad…

This study aims to create and check the accuracy of new tests that combine thinking tasks with arm movements. Researchers will compare 30 athletes and healthy adults to see if adding a mental challenge changes physical performance. The goal is to develop a reliable tool for asses…

This study looks at how a food-grade probiotic supplement affects the body and mind of healthy adults. Participants take one capsule daily for 1 or 6 months, complete online thinking tasks, and provide blood and stool samples. The goal is to see if the supplement is well tolerate…

This study tests whether a mild electrical pulse to the ear (taVNS) can temporarily improve attention, memory, and other thinking skills in 60 healthy adults aged 18-30. Each person will receive both the real stimulation and a fake (sham) version in separate sessions to compare e…

This study will follow 2,800 adults aged 55 and older in Hangzhou, China, for many years. Researchers will collect information on diet, lifestyle, thinking skills, brain scans, and gut bacteria. The goal is to learn more about healthy aging and cognitive decline, not to test a tr…

This pilot study tests a 6-week program called WISDOM that uses WhatsApp and in-person sessions to help older adults in Singapore improve their digital health skills and possibly support brain health. Researchers will compare 140 participants who join the program with those who c…

This study aims to see if the brain produces organized electrical signals in the minutes after the heart stops but before brain death is declared. Researchers will use a non-invasive head cap with sensors (EEG) and artificial intelligence to capture and store these signals. The s…

This study looks at whether trying different ways to plan physical activity helps inactive adults aged 60 and older become more active and improve their memory and thinking. Participants will wear a Fitbit for 9 months and complete short brain games on their phone. The goal is to…

This early-stage study looks at whether taking a ketosis supplement (which puts the body in a fat-burning state) combined with 30 minutes of treadmill walking can increase a brain protein called BDNF and improve memory and thinking. Researchers will compare the supplement to a pl…

The purpose of this study is to explore whether intensive music therapy can help improve cognitive functions like memory, attention, and decision-making skills in stroke patients who are undergoing rehabilitation. This is a feasibility study, meaning it's also designed to see ho…