Brain games and drugs: a new hope for psychosis?

NCT ID NCT07263022

Recruiting now Knowledge-focused Sponsor: University of Minnesota Source: ClinicalTrials.gov ↗

First seen Jun 25, 2026 · Last updated Jul 24, 2026 · Updated 4 times

Summary

This study looks at whether a single dose of modafinil or D-serine can improve decision-making and thinking in people who have had psychosis for less than five years. Twenty-four participants will play computer brain games and have brain scans before and after taking the drugs. The goal is to understand how these agents affect the brain, not to treat the condition directly.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: Modafinil and D-serine
What this could lead to: If it works, this could point toward treatments that improve thinking and decision-making in people with early psychosis.
What could go wrong: This is a small, early-stage study with only 24 participants. It tests single doses, not long-term effects, so results may not lead to new treatments.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

bipolar disorder cognitive disorder major depressive disorder psychiatric disorder psychotic disorder Psychotic Disorders schizoaffective disorder schizophrenia schizophreniform disorder

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

BIPOLAR DISORDER WITH PSYCHOTIC FEATURES COGNITION MAJOR DEPRESSIVE DISORDER WITH PSYCHOTIC FEATURES PSYCHOSIS PSYCHOSIS NOS PSYCHOTIC DISORDER SCHIZOAFFECTIVE DISORDER SCHIZOPHRENIA DISORDER SCHIZOPHRENIFORM DISORDER

Contacts and locations

Locations

University of Minnesota
RECRUITING

Minneapolis, Minnesota, 55455, United States

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