BIPOLAR DISORDER (BD)

This study tests if a wearable light device (Vielight RX Gamma) can safely improve symptoms of bipolar depression. Forty people with bipolar disorder will either get the active device or an inactive sham device, used in the clinic 5 days a week for 6 weeks. Researchers will measu…

This study tests a noninvasive magnetic stimulation technique (TMS) targeting brain areas linked to memory and vision. 88 adults with bipolar disorder in a stable phase will receive either real or sham stimulation over 5 days. The goal is to see if this approach safely improves c…

This study looks at whether a drug called ketamine, given through an IV, along with a type of talk therapy (DBT), can help reduce suicidal thoughts in people with borderline personality disorder and depression or bipolar disorder. About 120 adults will get either ketamine or a pl…

This study tests whether eating only during a set 8-hour window each day (time-restricted eating) can help people with bipolar disorder who are overweight and depressed lose weight and improve their mood. Forty adults will be randomly assigned to either the eating plan or a waitl…

This study is testing a new group therapy program called PEDAL, designed to help people with bipolar disorder manage rapid and intense mood swings. It combines traditional group sessions with new digital tools like an app-based mood diary and online skills training. Researchers w…

This study tests a new idea: that borderline personality disorder (BPD) may be a form of addiction to relationships. Researchers will compare 194 people with BPD, bipolar disorder, and healthy volunteers using questionnaires and brain-related tests. The goal is to better understa…

This study aims to improve how doctors diagnose bipolar disorder and predict future mood episodes. Researchers will use smartwatches to track sleep and activity, and simple computer tasks to measure decision-making in 600 people with bipolar disorder, major depression, or no mood…

This study looks at whether a new online program can help people with schizophrenia or bipolar disorder take their medication as prescribed. Researchers will use digital questionnaires and pharmacy records to measure adherence, then offer a telehealth support program to those who…

This study tests whether analyzing voice recordings can help predict upcoming depressive or manic episodes in people with bipolar disorder. Researchers will collect speech samples and lifestyle data from 170 adults recently discharged from the hospital or in remission. The goal i…