New trial combines lifestyle changes and Weight-Loss drug to boost mental health
NCT ID NCT07586150
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This study tests whether a personalized program of exercise, diet, sleep support, social activities, and a weight-loss drug (semaglutide) can improve mental functioning in 140 adults with depression, bipolar disorder, or schizophrenia. Participants are randomly assigned to the personalized program or a standard education group. The main goal is to see if mental health scores improve after 3 months.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
Semaglutide (a once-weekly injection for weight loss and metabolic health), plus personalized exercise, anti-inflammatory diet, sleep intervention, social prescribing, and optional brain stimulation
What this could lead to
If it works, this could point toward a practical, personalized treatment plan that improves mental and physical health for people with severe mental illness.
What could go wrong
This is an early-stage trial with only 140 participants, so results may not apply to everyone. The lifestyle changes require significant effort, and semaglutide can cause side effects like nausea or vomiting.
Disclaimer
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This is a summary of
the original study
.
Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Study contacts
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Contact
Phone: •••-•••-•••• Email: •••••@•••••
Locations
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Central Institute of Mental Health
Mannheim, 68159, Germany
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Department of Psychiatry and Psychotherapy, LMU Klinikum
München, 80336, Germany
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Medical University of Vienna
Vienna, 1090, Austria
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University Medical Center Groningen
Groningen, 9713 GZ, Netherlands
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University Medical Center Utrecht
Utrecht, 3584 CX, Netherlands