Targeted magnetic pulses aim to lift bipolar depression
NCT ID NCT07680153
First seen Jul 02, 2026 · Last updated Jul 02, 2026
Summary
This study tests whether a non-invasive brain stimulation technique called rTMS can improve depression in people with bipolar disorder. Researchers use brain scans to create a personalized map for each participant, targeting the exact brain circuits involved in mood shifts. Participants receive both active and sham (placebo) stimulation in random order to compare effects. The goal is to see if this tailored approach can restore communication between brain regions and reduce depressive symptoms.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- repetitive transcranial magnetic stimulation (rTMS)
- What this could lead to
- If it works, this could point toward a more effective, non-invasive treatment for depression in bipolar disorder that is tailored to each person's brain.
- What could go wrong
- This is a small, early-phase trial testing a new targeting method, so results may not apply broadly. rTMS can cause scalp discomfort or headache, and the sham comparison helps control for placebo effects.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Study contacts
-
Contact
Email: •••••@•••••
Locations
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Weill Cornell Medicine
New York, New York, 10065, United States
Contact Email: •••••@•••••
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