Targeted magnetic pulses aim to lift bipolar depression
NCT ID NCT07680153
First seen Jul 02, 2026 · Last updated Jul 02, 2026
Summary
This study tests whether a non-invasive brain stimulation technique called rTMS can improve depression in people with bipolar disorder. Researchers use brain scans to create a personalized map for each participant, targeting the exact brain circuits involved in mood shifts. Participants receive both active and sham (placebo) stimulation in random order to compare effects. The goal is to see if this tailored approach can restore communication between brain regions and reduce depressive symptoms.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
repetitive transcranial magnetic stimulation (rTMS)
What this could lead to
If it works, this could point toward a more effective, non-invasive treatment for depression in bipolar disorder that is tailored to each person's brain.
What could go wrong
This is a small, early-phase trial testing a new targeting method, so results may not apply broadly. rTMS can cause scalp discomfort or headache, and the sham comparison helps control for placebo effects.
Disclaimer
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the original study
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
More trials for these conditions
Other studies related to the condition(s) this trial covers.
- Biomarker-Guided Depression Treatment Trial NCT07680140
- Lumateperone vs Cariprazine for Bipolar Depressi NCT07676669
- B-HAPPI: Pramipexole for Bipolar Depression (NCT07664852)
- VR Cognitive Training for Schizophrenia & Bipola NCT07632989
- Early Mental Health Screening in Kids of Parents NCT07622927
- Flumazenil for ECT cognitive side effects (NCT07619092)
Contacts and locations
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Study contacts
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Contact
Phone: •••-•••-•••• Email: •••••@•••••
Locations
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Weill Cornell Medicine
New York, New York, 10065, United States
Contact
Contact Phone: •••-•••-•••• Email: •••••@•••••