BIPOLAR I DISORDER

This study is testing if a new combination medication (OLZ/SAM) causes less weight gain than the standard drug olanzapine in children and teenagers with schizophrenia or bipolar I disorder. About 220 participants, aged 10-17, will take either the new combination or standard olanz…

This study is testing whether an investigational medicine called azetukalner can help reduce depressive symptoms in adults with bipolar I or II disorder. About 400 participants will be randomly assigned to receive either the study drug or a placebo for 6 weeks. Researchers will m…

This study is testing whether an investigational oral medication called LB-102 can help reduce depressive symptoms in adults with Bipolar I Disorder. About 320 participants will be randomly assigned to take either LB-102 or a placebo pill daily for six weeks. Researchers will mea…

This study is testing whether a new investigational medicine called NBI-1117568 can help reduce severe manic symptoms in adults with bipolar I disorder who are currently hospitalized for a manic episode. The trial will compare the medicine to a placebo (an inactive substance) in …

This study aims to find the best weight loss medication for people with bipolar disorder by first identifying their specific eating patterns, like 'emotional hunger' or 'hungry gut.' Researchers will match 100 participants to one of three FDA-approved weight loss drugs or a no-me…

This study is testing whether a new drug called Icalcaprant can help control depressive episodes in adults with bipolar I or II disorder. About 195 participants will take either the drug or a placebo pill daily for six weeks, while continuing their current mood stabilizer medicat…

This study is testing if a medication called cariprazine can help control the depressive episodes in teenagers (ages 10-17) who have bipolar I disorder. About 380 teens will be randomly assigned to receive either the study drug or a placebo for 6 weeks, followed by safety checks.…

This study is testing if following a ketogenic diet (high-fat, very low-carb) alongside usual treatment can help people recently diagnosed with bipolar disorder or schizoaffective disorder. Researchers will measure if the diet changes how the brain uses energy and if it improves …

This study is testing if adding an over-the-counter magnesium and vitamin B6 supplement to standard treatment can help reduce symptoms of depression, anxiety, and stress in adults recently diagnosed with bipolar I disorder. Researchers will compare the supplement to a placebo (in…

This study aims to better understand how young people (ages 9-19) with bipolar disorder respond to treatment over one year. Researchers at four US clinics will follow 80 youth and their families, providing standard care while tracking mood, family relationships, and quality of li…

This study aims to see if using a visual life history calendar helps people in Hong Kong remember their mental health history more accurately. Researchers will compare the standard mental health interview with and without the calendar tool. The goal is to improve how we measure h…