New drug LB-102 aims to lift bipolar depression

NCT ID NCT07494305

Recruiting now Symptom relief Sponsor: LB Pharmaceuticals Inc. Source: ClinicalTrials.gov ↗

First seen Jun 26, 2026 · Last updated Jul 28, 2026 · Updated 3 times

Summary

This Phase 2 study tests whether LB-102 can reduce depressive symptoms in adults with bipolar I disorder who are currently in a major depressive episode. About 320 participants will receive either the drug or a placebo for 6 weeks. The main goal is to see if LB-102 improves depression scores more than placebo.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: LB-102 (N-methyl amisulpride)
What this could lead to: If successful, this could provide a new treatment option for depressive episodes in bipolar I disorder, potentially easing symptoms like low mood and loss of interest.
What could go wrong: This is an early Phase 2 trial with only 320 participants, so results may not confirm effectiveness. The drug may cause side effects or work no better than placebo.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

bipolar I disorder

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

BIPOLAR I DISORDER

Contacts and locations

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Study contacts

Contact

Email: •••••@•••••

Locations

Adams Clinical
RECRUITING

Philadelphia, Pennsylvania, 19104, United States
Adams Clinical
RECRUITING

DeSoto, Texas, 75115, United States

Contact Email: •••••@•••••
Arch Clinical Trials
RECRUITING

St Louis, Missouri, 63141, United States
CenExel
RECRUITING

Bellflower, California, 90706, United States
CenExel
RECRUITING

Garden Grove, California, 922845, United States
CenExel
RECRUITING

Riverside, California, 92506, United States
CenExel
RECRUITING

Torrance, California, 90504, United States
Cenexel Decatur GA
RECRUITING

Decatur, Georgia, 30030, United States
Cenexel Hollywood Florida
RECRUITING

Hollywood, Florida, 33019, United States
Health Synergy Clinical Research
RECRUITING

West Palm Beach, Florida, 33407, United States
Innovative Clinical Research
RECRUITING

Miami Lakes, Florida, 33016, United States
Manhattan Behavioral Medicine
RECRUITING

New York, New York, 10036, United States
NRC Research Institute
RECRUITING

Los Angeles, California, 90015, United States
NRC Research Institute
RECRUITING

Orange, California, 92868, United States
NSRT
RECRUITING

Detroit, Michigan, 48203, United States
Neuro-Behavioral Clinical Research
RECRUITING

Canton, Ohio, 44720, United States
Northwest Clinical Research Center
RECRUITING

Bellevue, Washington, 98007, United States
Pillar Clinical Research
RECRUITING

Bentonville, Arkansas, 72712, United States

Contact Email: •••••@•••••
Pillar Clinical Research
RECRUITING

Little Rock, Arkansas, 72204, United States

Contact Email: •••••@•••••
Pillar Clinical Research
RECRUITING

Chicago, Illinois, 60641, United States

Contact Email: •••••@•••••
Pillar Clinical Research
RECRUITING

Richardson, Texas, 75080, United States

Contact Email: •••••@•••••
ProScience Research Group
RECRUITING

Culver City, California, 90230, United States
Redbird Research
RECRUITING

Las Vegas, Nevada, 89119, United States

Contact Email: •••••@•••••
St. Jude Clinical Research
RECRUITING

Doral, Florida, 33172, United States
Synergy San Diego
RECRUITING

Lemon Grove, California, 91945, United States
Trialmed
RECRUITING

Atlanta, Georgia, 30328, United States

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