New drug LB-102 aims to lift bipolar depression
NCT ID NCT07494305
First seen Jun 26, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This Phase 2 study tests whether LB-102 can reduce depressive symptoms in adults with bipolar I disorder who are currently in a major depressive episode. About 320 participants will receive either the drug or a placebo for 6 weeks. The main goal is to see if LB-102 improves depression scores more than placebo.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
LB-102 (N-methyl amisulpride)
What this could lead to
If successful, this could provide a new treatment option for depressive episodes in bipolar I disorder, potentially easing symptoms like low mood and loss of interest.
What could go wrong
This is an early Phase 2 trial with only 320 participants, so results may not confirm effectiveness. The drug may cause side effects or work no better than placebo.
Disclaimer
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the original study
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Study contacts
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Contact
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Contact
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Locations
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Adams Clinical
RECRUITINGPhiladelphia, Pennsylvania, 19104, United States
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Adams Clinical
RECRUITINGDeSoto, Texas, 75115, United States
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Arch Clinical Trials
RECRUITINGSt Louis, Missouri, 63141, United States
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CenExel
RECRUITINGBellflower, California, 90706, United States
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CenExel
RECRUITINGGarden Grove, California, 922845, United States
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CenExel
RECRUITINGRiverside, California, 92506, United States
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CenExel
RECRUITINGTorrance, California, 90504, United States
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Cenexel Decatur GA
RECRUITINGDecatur, Georgia, 30030, United States
Contact Email: •••••@•••••
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Cenexel Hollywood Florida
RECRUITINGHollywood, Florida, 33019, United States
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Health Synergy Clinical Research
RECRUITINGWest Palm Beach, Florida, 33407, United States
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Innovative Clinical Research
RECRUITINGMiami Lakes, Florida, 33016, United States
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Manhattan Behavioral Medicine
RECRUITINGNew York, New York, 10036, United States
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NRC Research Institute
RECRUITINGLos Angeles, California, 90015, United States
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NRC Research Institute
RECRUITINGOrange, California, 92868, United States
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NSRT
RECRUITINGDetroit, Michigan, 48203, United States
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Neuro-Behavioral Clinical Research
RECRUITINGCanton, Ohio, 44720, United States
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Northwest Clinical Research Center
RECRUITINGBellevue, Washington, 98007, United States
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Pillar Clinical Research
RECRUITINGBentonville, Arkansas, 72712, United States
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Pillar Clinical Research
RECRUITINGLittle Rock, Arkansas, 72204, United States
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Pillar Clinical Research
RECRUITINGChicago, Illinois, 60641, United States
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Pillar Clinical Research
RECRUITINGRichardson, Texas, 75080, United States
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ProScience Research Group
RECRUITINGCulver City, California, 90230, United States
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Redbird Research
RECRUITINGLas Vegas, Nevada, 89119, United States
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St. Jude Clinical Research
RECRUITINGDoral, Florida, 33172, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Synergy San Diego
RECRUITINGLemon Grove, California, 91945, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Trialmed
RECRUITINGAtlanta, Georgia, 30328, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••