New pill aims to tame manic episodes in bipolar disorder

NCT ID NCT07288320

Recruiting now Symptom relief Sponsor: Neurocrine Biosciences Source: ClinicalTrials.gov ↗

First seen Jun 24, 2026 · Last updated Jul 31, 2026 · Updated 2 times

Summary

This study tests an experimental drug called NBI-1117568 for adults with bipolar I disorder who are hospitalized for a manic episode. Half of the 150 participants will get the drug, half a placebo, to see if it safely reduces manic symptoms over 21 days. The goal is to find a new treatment option for acute mania.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: NBI-1117568
What this could lead to: If successful, this could lead to a new medication to quickly reduce manic symptoms in bipolar I disorder.
What could go wrong: This is an early Phase 2 trial with only 150 participants, so results may not apply to everyone. The drug may not work better than placebo, and side effects are still being studied.

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Conditions

The condition(s) this trial relates to.

bipolar I disorder Mania

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

BIPOLAR I DISORDER MANIA

Contacts and locations

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Study contacts

Contact

Email: •••••@•••••

Locations

Neurocrine Clinical Site
RECRUITING

Little Rock, Arkansas, 72211, United States
Neurocrine Clinical Site
RECRUITING

Garden Grove, California, 92845, United States
Neurocrine Clinical Site
RECRUITING

San Diego, California, 92123, United States
Neurocrine Clinical Site
RECRUITING

Hollywood, Florida, 33024, United States
Neurocrine Clinical Site
RECRUITING

Atlanta, Georgia, 30331, United States
Neurocrine Clinical Site
RECRUITING

Gaithersburg, Maryland, 20877, United States
Neurocrine Clinical Site
RECRUITING

Marlton, New Jersey, 08053, United States
Neurocrine Clinical Site
RECRUITING

Staten Island, New York, 10314, United States
Neurocrine Clinical Site
RECRUITING

Austin, Texas, 78754, United States

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