BIPOLAR I DISORDER

This 12-week study is for people who completed a previous trial of the ketogenic diet for first-episode bipolar disorder. Researchers want to see if the diet can improve symptoms like depression, mania, and psychosis, as well as brain energy metabolism and insulin resistance. Abo…

This study is testing the long-term safety of a daily pill called OLZ/SAM (olanzapine plus samidorphan) in 236 teenagers with schizophrenia or bipolar I disorder. Participants have already completed a previous study with the same drug. The goal is to see if the drug is safe and t…

This Phase 3 study tests the long-term safety and effectiveness of azetukalner, a daily pill, in 400 adults with bipolar I or II depression who previously completed a related study. Participants take the drug for 52 weeks, and researchers track side effects, mood changes, and qua…

This large study compares four FDA-approved medications for bipolar depression to see which one helps people feel better. Over 2,700 adults with bipolar I or II disorder and current depression will be randomly assigned to one of the drugs. The goal is to find which treatment lead…

This small study tests a new treatment called TEST for people with depression that hasn't improved with standard treatments. TEST uses a lower electric current than standard electroconvulsive therapy (ECT), aiming to avoid memory and thinking problems. Eight adults aged 25-64 wil…

This study tests whether a single injection of ketamine can quickly reduce suicidal thoughts in people with depression who come to the emergency room. About 90 participants will receive either ketamine or a sedative (midazolam) and be monitored for 24 hours. The trial is currentl…

This study looks at whether moderate-to-vigorous aerobic exercise, called Braining, can help people with bipolar depression recover faster and prevent future depressive episodes. Fifty-four participants will be split into three groups: one doing supervised aerobic exercise three …

This study aimed to see if a dissolvable film placed under the tongue could quickly calm agitation in people with bipolar disorder or schizophrenia who come to the emergency room. The drug, BXCL501, is already approved for this use, but the study wanted to test it in the ER setti…

This study was designed to explore how cariprazine (Vraylar) might help people with bipolar depression by looking at its effect on a specific brain receptor (D3 dopamine). Participants would have taken cariprazine for six weeks and undergone PET scans to see how the drug works in…

This study looks at how low field magnetic stimulation changes brain activity in older adults (age 60+) with bipolar depression. Forty participants receive both real and sham (fake) stimulation on separate days, with brain scans taken before and after each session. The goal is to…

This study observes the safety of ADASUVE (loxapine inhalation) in up to 10,000 adults with agitation from schizophrenia or bipolar I disorder. It tracks side effects in real-world emergency or inpatient settings. The study is observational, meaning no new treatment is given—just…

This study is testing whether data from smartphones and wearable devices can predict when a person with depression or bipolar disorder might have another episode. Over 12 months, 540 participants will wear a Fitbit, log daily moods, and complete five check-ins. Researchers will u…