BIPOLAR I DISORDER

This study tested the long-term safety of cariprazine, a medication, in children and teenagers with schizophrenia, bipolar I disorder, or autism spectrum disorder. Over 300 participants took flexible doses of the medication for 52 weeks while researchers monitored for side effect…

This study tested whether regular ketamine infusions could help maintain relief from severe bipolar depression in people who initially responded to the treatment. Forty-one adults with treatment-resistant bipolar depression received flexible-dose ketamine infusions every 2-4 week…

This study tested whether repeated low-dose ketamine infusions could help people with treatment-resistant bipolar depression. 71 participants who hadn't responded to standard medications received either ketamine or a sedative placebo over two weeks. Researchers measured changes i…

This study compared a new tablet called VHX-896 to an existing drug, iloperidone, in people with schizophrenia or bipolar I disorder. The main goal was to see if the new tablet gets into the bloodstream the same way as the old one. Researchers also checked how safe and tolerable …

This study tested whether a new oral medication called ABBV-932 could safely help reduce depressive symptoms in adults with bipolar I or II disorder. About 160 participants worldwide were randomly assigned to receive either the drug or a placebo pill daily for six weeks. Research…

This study observed how well the medication cariprazine (brand name Vraylar) worked for adults with bipolar I disorder who were experiencing a depressive episode. About 120 patients from the US and Canada were followed for up to 24 weeks in their normal treatment settings. Resear…

This study tested a medication called BXCL501 to see if it could safely and effectively calm episodes of agitation when used at home by adults with schizophrenia or bipolar disorder. In the second part of the trial, 452 participants used the medication as needed over 12 weeks at …

This study aimed to find out if a person's voice and speech change when they are experiencing a manic episode from bipolar disorder. Researchers recorded and analyzed the speech of 17 hospitalized patients during mania, looking at things like pitch, rhythm, sentence structure, an…