BIPOLAR I DISORDER

This study tested whether a new drug, VHX-896, works similarly in the body to the approved medication iloperidone. 26 adults with stable schizophrenia or bipolar I disorder took both drugs to compare their effects and safety. The goal was to see if VHX-896 could be a future treat…

This study looked at the long-term safety of the drug cariprazine in 310 children and teens with schizophrenia, bipolar I disorder, or autism spectrum disorder. Over 52 weeks, researchers monitored side effects, movement changes, and lab results. The goal was to understand the ri…

This study tested an experimental drug called ABBV-932 in 161 adults with bipolar I or II disorder who were currently experiencing a depressive episode. Participants took either the drug or a placebo daily for 6 weeks to see if it safely improves mood and reduces depression sympt…

This study looked at whether repeated low-dose ketamine infusions could help people with treatment-resistant bipolar depression keep feeling better over 12 weeks. Forty-one adults who had already responded to an initial course of ketamine received up to six more infusions on a fl…

This study followed 120 adults with bipolar I disorder who were starting cariprazine (Vraylar) for a depressive episode. Researchers measured changes in depression symptoms, daily functioning, and quality of life over 24 weeks in routine clinic visits. The goal was to see how wel…

This early-stage study tested the safety of a new drug called MK-8189 (elpipodect) in 34 adults with stable bipolar I disorder. Participants took multiple doses of the drug, and researchers monitored for side effects. The study did not test whether the drug works; it only looked …

This study tested an investigational medication called BXCL501 for calming agitation episodes in people with bipolar disorder, schizophrenia, or related conditions. 452 adults took either the drug or a placebo, and researchers measured changes in agitation levels and safety. The …

This study tested four doses of intravenous ketamine in 71 adults with treatment-resistant bipolar depression. Participants received either ketamine or a sedative (midazolam) over two weeks. The goal was to see if ketamine could safely reduce depression symptoms. Results focused …

This study looked at whether voice and speech patterns change during manic episodes in people with Bipolar I Disorder. Researchers recorded and analyzed audio from 17 hospitalized participants, focusing on pitch, rhythm, response time, sentence structure, and word choice. The goa…

This study looked at whether a program called NAVIGATE helps youth (ages 14-35) having their first episode of psychosis get better coordinated care. Researchers worked with 100 participants across Ontario to see if the program reduces hospital stays and ER visits. The goal was to…

This study looked at whether family members or caregivers can help measure agitation in people with bipolar disorder or schizophrenia. 33 adults took a single dose of an experimental medicine, and researchers compared ratings from doctors, patients, and their family members. The …