Ketamine shows promise for bipolar depression in new trial

NCT ID NCT05004896

First seen Nov 01, 2025 · Last updated Apr 24, 2026 · Updated 22 times

Summary

This study tested four doses of intravenous ketamine in 71 adults with treatment-resistant bipolar depression. Participants received either ketamine or a sedative (midazolam) over two weeks. The goal was to see if ketamine could safely reduce depression symptoms. Results focused on changes in depression scores and side effects.

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Contacts and locations

Locations

  • Ontario Shores Centre for Mental Health Sciences

    Whitby, Ontario, L1N 5S9, Canada

  • Toronto General Hospital

    Toronto, Ontario, M5G 2C4, Canada

  • Toronto Western Hospital

    Toronto, Ontario, M5T 2S8, Canada

Conditions

Explore the condition pages connected to this study.