Can a single psychedelic dose rewire the depressed brain?

This pilot study is testing whether one 25 mg dose of psilocybin, given alongside psychotherapy, can ease depression in people with bipolar II disorder who haven't responded to at least two prior treatments. Using brain scans (fMRI), researchers will look at how the drug affects the amygdala, a brain region involved in emotion, and whether changes there relate to mood improvements. The study involves 30 adults and will also check if the approach is practical and acceptable to participants.