New drug combo aims to tackle bipolar depression and suicidal thoughts
NCT ID NCT05779267
First seen Jun 30, 2026 · Last updated Jul 01, 2026 · Updated 1 time
Summary
This study offers NRX-101, a combination of two drugs, to adults aged 18-65 with treatment-resistant bipolar depression and suicidal thoughts. Participants receive the medication from their own psychiatrist and undergo regular check-ins on mood, suicidal ideation, and side effects. The goal is to see if NRX-101 can help when standard treatments have failed.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
NRX-101 (D-cycloserine/lurasidone fixed dose combination)
What this could lead to
If successful, this could provide a new treatment option for people with bipolar depression who have not responded to other medications and are at risk of self-harm.
What could go wrong
This is an expanded access study, not a controlled trial, so results may be less reliable. The drug may cause side effects or not work for everyone.
Disclaimer
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This is a summary of
the original study
.
Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.