New combo therapy shows promise in preventing bipolar relapse

NCT ID NCT00277212

Completed Disease control Sponsor: Otsuka Pharmaceutical Development & Commercialization, Inc. Source: ClinicalTrials.gov ↗

First seen May 15, 2026 · Last updated May 15, 2026

Summary

This study tested whether adding aripiprazole to lamotrigine helps prevent mood episodes in people with bipolar I disorder who recently had a manic or mixed episode. Over 1,100 adults took part and were followed for up to a year. The main goal was to see if the combination reduced the chance of relapse into mania or mixed states.

Disclaimer Read more

This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.

Get updates

Get notified about this study

Our safety recommendation!

By submitting, you agree to our Terms of use

Contacts and locations

Show contact details

Locations

Act Clinical Research Institute, Llc

Daytona Beach, Florida, 32124, United States
Alamo Superior Research

San Antonio, Texas, 78229, United States
Aurora Health Care

Milwaukee, Wisconsin, 53233, United States
Aurora-Cuervo Clinical Trials

Miami, Florida, 33143, United States
Bayou City Research, Ltd.

Houston, Texas, 77007, United States
Belmont Center For Comprehensive Treatment

Philadelphia, Pennsylvania, 19131, United States
Buffalo Psychiatric Center

Buffalo, New York, 14213, United States
Capital Clinical Research Associates

Rockville, Maryland, 20852, United States
Clinco

Terre Haute, Indiana, 47802, United States
Clinical Insights

Glen Burnie, Maryland, 21061, United States
Clinical Research Institute

Wichita, Kansas, 67213, United States
Clinical Trials Technology, Inc

Prairie Village, Kansas, 66206, United States
Cns Clinical Research Group

Coral Springs, Florida, 33065, United States
Cns Research Institute

Philadelphia, Pennsylvania, 19149, United States
College Hospital Costa Mesa

Costa Mesa, California, 92627, United States
Community Research

Cincinnati, Ohio, 45227, United States
Comprehensive Neuroscience, Inc

Atlanta, Georgia, 30328, United States
Cutting Edge Research

Oklahoma City, Oklahoma, 73116, United States
Dubois Regional Medical Center

DuBois, Pennsylvania, 15801, United States
Duke University Medical Center

Durham, North Carolina, 27705, United States
Excell Research

Oceanside, California, 92056, United States
Finger Lakes Clinical Research

Rochester, New York, 14618, United States
Freimer, Martin

East Stroudsburg, Pennsylvania, 18301, United States
Gulf Coast Medical Research

Port Charlotte, Florida, 33952, United States
Harmony Research, Llc

Piney Flats, Tennessee, 37686, United States
Health Research Center

Morgantown, West Virginia, 26506, United States
Health Sciences America, Llc

Boca Raton, Florida, 33432, United States
Horizon Medical Services

Bismarck, North Dakota, 58501, United States
Janus Center For Psychiatric Research

West Palm Beach, Florida, 33407, United States
Lehigh Center For Clinical Research

Allentown, Pennsylvania, 18104, United States
Lehigh Valley Hospital

Allentown, Pennsylvania, 18103, United States
Local Institution

Cabo Rojo, 00623, Puerto Rico
Local Institution

Ponce, 00731, Puerto Rico
Local Institution

Rio Piedras, 00926, Puerto Rico
Local Institution

San Juan, 00918, Puerto Rico
Los Angeles Biomedical Research Institute

Torrance, California, 90502, United States
Neuro Behavioral Clinical Research, Inc.

Canton, Ohio, 44708, United States
Neuropsychiatric Research Center Of Southwest Florida

Fort Myers, Florida, 33912, United States
Owensboro Behavioral Care

Owensboro, Kentucky, 42301, United States
Pacific Clinical Research Medical Group

Upland, California, 91786, United States
Pacific Institute For Medical Research, Inc.

Los Angeles, California, 90024, United States
Pacific Institute Of Medical Sciences

Bothell, Washington, 98011, United States
Pravin Kansagra, M.D.

Anaheim, California, 92801, United States
Precise Research Centers

Flowood, Mississippi, 39232, United States
Psychiatric Consultants, Pc

Nashville, Tennessee, 37203, United States
Psychopharmacology Research Corporation

Farmington Hills, Michigan, 48334, United States
Regions Hospital

Saint Paul, Minnesota, 55101, United States
Richmond Behavioral Associates

Staten Island, New York, 10312, United States
Saroj Brar Md, Inc

Cleveland, Ohio, 44113, United States
Sheppard Pratt Health System

Baltimore, Maryland, 21285, United States
Southern Ca Clinical Research, Inc.

Pasadena, California, 91106, United States
Southwest Biomedical Research Foundation

Tucson, Arizona, 85712, United States
Stanford University

Stanford, California, 94305, United States
Summit Research Network

Portland, Oregon, 97210, United States
Summit Research Network (Seattle) Llc

Seattle, Washington, 98104, United States
University Of Alabama At Birmingham

Birmingham, Alabama, 35205, United States
University Of Kentucky, Dept. Of Psychiatry

Lexington, Kentucky, 40509, United States
University Of Medicine & Dentistry Of New Jersey

Cherry Hill, New Jersey, 08002, United States
University Of Minnesota

Minneapolis, Minnesota, 55455, United States
University Of Oklahoma Health Sciences Center

Oklahoma City, Oklahoma, 73104, United States
University Of Pennsylvania

Philadelphia, Pennsylvania, 19104, United States
University Of Virginia Health System

Charlottesville, Virginia, 22903, United States
Ut Medical Group/Odyssey Research

Memphis, Tennessee, 38105, United States
Valle Vista Health System

Greenwood, Indiana, 46143, United States
Windwood Centre

Virginia Beach, Virginia, 23452, United States
Zarzar Psychiatric Associates, Pllc

Raleigh, North Carolina, 27607, United States

Conditions

Explore the condition pages connected to this study.

BIPOLAR DISORDER