Ketamine boost: can maintenance doses keep bipolar depression at bay?

NCT ID NCT05339074

First seen Sep 30, 2025 · Last updated May 18, 2026 · Updated 33 times

Summary

This study looked at whether repeated ketamine infusions can help adults with treatment-resistant bipolar depression maintain their mood improvement. Forty-one people who had already responded to an initial course of ketamine received up to six more infusions over 12 weeks. The goal was to see if flexible dosing every 2-4 weeks could keep depression from returning while being safe and well-tolerated.

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Contacts and locations

Locations

  • Ontario Shores Centre for Mental Health Sciences

    Whitby, Ontario, L1N 5S9, Canada

  • Toronto General Hospital

    Toronto, Ontario, M5G 2C4, Canada

  • Toronto Western Hospital

    Toronto, Ontario, M5T 2S8, Canada

Conditions

Explore the condition pages connected to this study.