Ketamine infusions help sustain mood gains in tough-to-treat bipolar depression

NCT ID NCT05339074

First seen Sep 30, 2025 · Last updated May 05, 2026 · Updated 31 times

Summary

This study looked at whether repeated ketamine infusions could keep depression symptoms away in people with bipolar disorder who had already responded to an initial course of ketamine. Forty-one adults who completed a prior ketamine trial received up to six additional infusions over 12 weeks. The goal was to see if flexible dosing could maintain antidepressant effects safely without triggering mania.

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Contacts and locations

Locations

  • Ontario Shores Centre for Mental Health Sciences

    Whitby, Ontario, L1N 5S9, Canada

  • Toronto General Hospital

    Toronto, Ontario, M5G 2C4, Canada

  • Toronto Western Hospital

    Toronto, Ontario, M5T 2S8, Canada

Conditions

Explore the condition pages connected to this study.