Could CBD ease anxiety in bipolar disorder? new trial aims to find out

NCT ID NCT05457465

Recruiting now Symptom relief Sponsor: Mclean Hospital Source: ClinicalTrials.gov ↗

First seen Jun 26, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This phase 2 trial is testing a custom, THC-free CBD product to see if it can reduce anxiety and depression in people with bipolar disorder. Twenty-five adults with bipolar I or II who have at least moderate anxiety will take the CBD daily for 4 weeks. Researchers will measure changes in anxiety and depression using standard rating scales.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: cannabidiol (CBD)
What this could lead to: If it works, this could point toward a new option for managing anxiety and depression in people with bipolar disorder.
What could go wrong: This is a small, early-phase open-label trial with no placebo group, so results may not be reliable. CBD may also cause side effects like drowsiness or interactions with other medications.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

bipolar disorder

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

BIPOLAR DISORDER

Contacts and locations

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Study contacts

Contact

Email: •••••@•••••

Locations

McLean Hospital
RECRUITING

Belmont, Massachusetts, 02478, United States

Contact Email: •••••@•••••

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