Can sound waves calm both seizures and anxiety?
NCT ID NCT05032105
First seen Jul 22, 2026 · Last updated Jul 23, 2026 · Updated 1 time
Summary
This early-stage trial is testing whether a non-invasive procedure called focused ultrasound can safely reduce both seizures and anxiety in people with treatment-resistant epilepsy. The ultrasound targets a small region in the brain thought to be involved in both conditions. Researchers are evaluating safety, changes in anxiety symptoms, and brain responses to threat.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- Magnetic Resonance Imaging-guided Focused Ultrasound Ablation (MRgFUSA) — a non-invasive procedure that uses ultrasound waves to target a small area in the brain
- What this could lead to
- If it works, this could offer a non-invasive surgical option for people with epilepsy and anxiety who have not responded to medication.
- What could go wrong
- This is a very early, small trial with only 2 participants, so results may not apply broadly. The procedure involves creating a brain lesion, which carries risks like swelling, bleeding, or neurological changes.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Locations
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The Ohio State University
Columbus, Ohio, 43210, United States
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