Could a glass of Alcohol-Free wine boost your brain?

NCT ID NCT05541887

Terminated Disease control Sponsor: University of Florida Source: ClinicalTrials.gov ↗

First seen Aug 10, 2026 · Last updated Aug 11, 2026 · Updated 1 time

Summary

This study tests whether polyphenols from muscadine wine, served as a non-alcoholic beverage, can improve cognitive performance, memory, mood, and anxiety in healthy adults over 50. Participants will drink either the polyphenol-rich beverage or a placebo and complete a series of brain and mood tests. Researchers will also measure blood markers related to stress, inflammation, and brain chemicals to understand how the polyphenols might work.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: Dealcoholized muscadine wine polyphenols (a beverage with less than 0.5% alcohol)
What this could lead to: If it works, this could point toward a natural dietary approach to support brain health and emotional well-being in older adults.
What could go wrong: This is a small, early-stage trial with only 25 participants, so results may not apply broadly. The effects could be modest, and the beverage is not a treatment for any disease.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

anxiety anxiety disorder mood disorder

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

ANXIETY COGNITIVE PERFORMANCE MEMORY MOOD

Contacts and locations

Locations

Food Science and human nutrition department at University of Florida

Gainesville, Florida, 32611, United States

More trials for these conditions

Other studies related to the condition(s) this trial covers.