Gut feeling: probiotic shows promise for easing anxiety and depression

NCT ID NCT07353320

Completed Symptom relief Sponsor: Wecare Probiotics Co., Ltd. Source: ClinicalTrials.gov ↗

First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study tested whether a probiotic called Weizmannia coagulans BC99 can reduce symptoms of anxiety and depression in stressed adults. 79 people took either the probiotic or a placebo for 8 weeks. Researchers measured changes using standard depression and anxiety rating scales. The goal was to see if improving gut bacteria could boost mental health.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: Weizmannia coagulans BC99 (a probiotic)
What this could lead to: If it works, this could point toward a simple, natural supplement to help manage mild anxiety and depression.
What could go wrong: This is a small, early-stage trial with only 79 people. The effect may be small or no better than placebo, and results may not apply to everyone with anxiety or depression.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

anxiety depressive disorder mixed anxiety and depressive disorder

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

ANXIETY DEPRESSION

Contacts and locations

Locations

Henan University of Science and Technolog

Luoyang, Henan, 462000, China

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